Cargando…

Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded m...

Descripción completa

Detalles Bibliográficos
Autores principales: Bowring, Janine, Neamah, Maan M, Donderis, Jorge, Mir-Sanchis, Ignacio, Alite, Christian, Ciges-Tomas, J Rafael, Maiques, Elisa, Medmedov, Iltyar, Marina, Alberto, Penadés, José R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779228/
https://www.ncbi.nlm.nih.gov/pubmed/28826473
http://dx.doi.org/10.7554/eLife.26487
_version_ 1783294498264055808
author Bowring, Janine
Neamah, Maan M
Donderis, Jorge
Mir-Sanchis, Ignacio
Alite, Christian
Ciges-Tomas, J Rafael
Maiques, Elisa
Medmedov, Iltyar
Marina, Alberto
Penadés, José R
author_facet Bowring, Janine
Neamah, Maan M
Donderis, Jorge
Mir-Sanchis, Ignacio
Alite, Christian
Ciges-Tomas, J Rafael
Maiques, Elisa
Medmedov, Iltyar
Marina, Alberto
Penadés, José R
author_sort Bowring, Janine
collection PubMed
description Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle. Different SaPIs encode different Stl repressors, so each targets a specific phage protein for its de-repression. Broadening this narrow vision, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechanisms. This is accomplished because the SaPI Stl repressors have acquired different domains to interact with unrelated proteins, encoded by different phages, but in all cases performing the same conserved function. This elegant strategy allows intra- and inter-generic SaPI transfer, highlighting these elements as one of nature’s most fascinating subcellular parasites.
format Online
Article
Text
id pubmed-5779228
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-57792282018-01-25 Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer Bowring, Janine Neamah, Maan M Donderis, Jorge Mir-Sanchis, Ignacio Alite, Christian Ciges-Tomas, J Rafael Maiques, Elisa Medmedov, Iltyar Marina, Alberto Penadés, José R eLife Microbiology and Infectious Disease Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle. Different SaPIs encode different Stl repressors, so each targets a specific phage protein for its de-repression. Broadening this narrow vision, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechanisms. This is accomplished because the SaPI Stl repressors have acquired different domains to interact with unrelated proteins, encoded by different phages, but in all cases performing the same conserved function. This elegant strategy allows intra- and inter-generic SaPI transfer, highlighting these elements as one of nature’s most fascinating subcellular parasites. eLife Sciences Publications, Ltd 2017-08-08 /pmc/articles/PMC5779228/ /pubmed/28826473 http://dx.doi.org/10.7554/eLife.26487 Text en © 2017, Bowring et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Microbiology and Infectious Disease
Bowring, Janine
Neamah, Maan M
Donderis, Jorge
Mir-Sanchis, Ignacio
Alite, Christian
Ciges-Tomas, J Rafael
Maiques, Elisa
Medmedov, Iltyar
Marina, Alberto
Penadés, José R
Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title_full Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title_fullStr Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title_full_unstemmed Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title_short Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
title_sort pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
topic Microbiology and Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779228/
https://www.ncbi.nlm.nih.gov/pubmed/28826473
http://dx.doi.org/10.7554/eLife.26487
work_keys_str_mv AT bowringjanine piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT neamahmaanm piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT donderisjorge piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT mirsanchisignacio piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT alitechristian piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT cigestomasjrafael piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT maiqueselisa piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT medmedoviltyar piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT marinaalberto piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer
AT penadesjoser piratingconservedphagemechanismspromotespromiscuousstaphylococcalpathogenicityislandtransfer