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Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779228/ https://www.ncbi.nlm.nih.gov/pubmed/28826473 http://dx.doi.org/10.7554/eLife.26487 |
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author | Bowring, Janine Neamah, Maan M Donderis, Jorge Mir-Sanchis, Ignacio Alite, Christian Ciges-Tomas, J Rafael Maiques, Elisa Medmedov, Iltyar Marina, Alberto Penadés, José R |
author_facet | Bowring, Janine Neamah, Maan M Donderis, Jorge Mir-Sanchis, Ignacio Alite, Christian Ciges-Tomas, J Rafael Maiques, Elisa Medmedov, Iltyar Marina, Alberto Penadés, José R |
author_sort | Bowring, Janine |
collection | PubMed |
description | Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle. Different SaPIs encode different Stl repressors, so each targets a specific phage protein for its de-repression. Broadening this narrow vision, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechanisms. This is accomplished because the SaPI Stl repressors have acquired different domains to interact with unrelated proteins, encoded by different phages, but in all cases performing the same conserved function. This elegant strategy allows intra- and inter-generic SaPI transfer, highlighting these elements as one of nature’s most fascinating subcellular parasites. |
format | Online Article Text |
id | pubmed-5779228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57792282018-01-25 Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer Bowring, Janine Neamah, Maan M Donderis, Jorge Mir-Sanchis, Ignacio Alite, Christian Ciges-Tomas, J Rafael Maiques, Elisa Medmedov, Iltyar Marina, Alberto Penadés, José R eLife Microbiology and Infectious Disease Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle. Different SaPIs encode different Stl repressors, so each targets a specific phage protein for its de-repression. Broadening this narrow vision, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechanisms. This is accomplished because the SaPI Stl repressors have acquired different domains to interact with unrelated proteins, encoded by different phages, but in all cases performing the same conserved function. This elegant strategy allows intra- and inter-generic SaPI transfer, highlighting these elements as one of nature’s most fascinating subcellular parasites. eLife Sciences Publications, Ltd 2017-08-08 /pmc/articles/PMC5779228/ /pubmed/28826473 http://dx.doi.org/10.7554/eLife.26487 Text en © 2017, Bowring et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Microbiology and Infectious Disease Bowring, Janine Neamah, Maan M Donderis, Jorge Mir-Sanchis, Ignacio Alite, Christian Ciges-Tomas, J Rafael Maiques, Elisa Medmedov, Iltyar Marina, Alberto Penadés, José R Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title | Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title_full | Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title_fullStr | Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title_full_unstemmed | Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title_short | Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
title_sort | pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer |
topic | Microbiology and Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779228/ https://www.ncbi.nlm.nih.gov/pubmed/28826473 http://dx.doi.org/10.7554/eLife.26487 |
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