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Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

BACKGROUND: Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the mechanism of action of flavopiridol as an anti-cancer agent has not been fully elucidated. RESULTS: Using DNA microarra...

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Detalles Bibliográficos
Autores principales:	Lam, Lloyd T, Pickeral, Oxana K, Peng, Amy C, Rosenwald, Andreas, Hurt, Elaine M, Giltnane, Jena M, Averett, Lauren M, Zhao, Hong, Davis, R Eric, Sathyamoorthy, Mohan, Wahl, Larry M, Harris, Eric D, Mikovits, Judy A, Monks, Anne P, Hollingshead, Melinda G, Sausville, Edward A, Staudt, Louis M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2001
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC57796/ https://www.ncbi.nlm.nih.gov/pubmed/11597333

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