Modeling specific action potentials in the human atria based on a minimal single-cell model

We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a charact...

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Detalles Bibliográficos
Autores principales: Richter, Yvonne, Lind, Pedro G., Maass, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779667/
https://www.ncbi.nlm.nih.gov/pubmed/29360837
http://dx.doi.org/10.1371/journal.pone.0190448
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author Richter, Yvonne
Lind, Pedro G.
Maass, Philipp
author_facet Richter, Yvonne
Lind, Pedro G.
Maass, Philipp
author_sort Richter, Yvonne
collection PubMed
description We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out.
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spelling pubmed-57796672018-02-08 Modeling specific action potentials in the human atria based on a minimal single-cell model Richter, Yvonne Lind, Pedro G. Maass, Philipp PLoS One Research Article We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this model, three ionic are currents introduced, where each of it is governed by a characteristic time scale. By applying a nonlinear optimization procedure, a best combination of the respective time scales is determined, which allows one to reproduce specific action potentials with a given amplitude, width and shape. Possible applications for supporting clinical diagnosis are pointed out. Public Library of Science 2018-01-23 /pmc/articles/PMC5779667/ /pubmed/29360837 http://dx.doi.org/10.1371/journal.pone.0190448 Text en © 2018 Richter et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Richter, Yvonne
Lind, Pedro G.
Maass, Philipp
Modeling specific action potentials in the human atria based on a minimal single-cell model
title Modeling specific action potentials in the human atria based on a minimal single-cell model
title_full Modeling specific action potentials in the human atria based on a minimal single-cell model
title_fullStr Modeling specific action potentials in the human atria based on a minimal single-cell model
title_full_unstemmed Modeling specific action potentials in the human atria based on a minimal single-cell model
title_short Modeling specific action potentials in the human atria based on a minimal single-cell model
title_sort modeling specific action potentials in the human atria based on a minimal single-cell model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779667/
https://www.ncbi.nlm.nih.gov/pubmed/29360837
http://dx.doi.org/10.1371/journal.pone.0190448
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