A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication

For adoptive cell transfer (ACT) immunotherapy of tumor-reactive T cells, an effective therapeutic outcome depends upon cell dose, cell expansion in vivo through a minimally differentiated phenotype, long term persistence, and strong cytolytic effector function. An incomplete understanding of the bi...

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Detalles Bibliográficos
Autores principales: Zhou, Jing, Bethune, Michael T., Malkova, Natalia, Sutherland, Alexander M., Comin-Anduix, Begonya, Su, Yapeng, Baltimore, David, Ribas, Antoni, Heath, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779691/
https://www.ncbi.nlm.nih.gov/pubmed/29360859
http://dx.doi.org/10.1371/journal.pone.0191634

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