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Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1

The role of killer cell immunoglobulin-like receptors (KIRs) in the transmission of HIV-1 has not been extensively studied. Here, we investigated the association of KIR gene content polymorphisms with perinatal HIV-1 transmission. The KIR gene family comprising 16 genes was genotyped in 313 HIV-1 po...

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Autores principales: Omosun, Yusuf O., Blackstock, Anna J., Williamson, John, van Eijk, Anne Maria, Ayisi, John, Otieno, Juliana, Lal, Renu B., ter Kuile, Feiko O., Slutsker, Laurence, Shi, Ya Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779696/
https://www.ncbi.nlm.nih.gov/pubmed/29360870
http://dx.doi.org/10.1371/journal.pone.0191733
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author Omosun, Yusuf O.
Blackstock, Anna J.
Williamson, John
van Eijk, Anne Maria
Ayisi, John
Otieno, Juliana
Lal, Renu B.
ter Kuile, Feiko O.
Slutsker, Laurence
Shi, Ya Ping
author_facet Omosun, Yusuf O.
Blackstock, Anna J.
Williamson, John
van Eijk, Anne Maria
Ayisi, John
Otieno, Juliana
Lal, Renu B.
ter Kuile, Feiko O.
Slutsker, Laurence
Shi, Ya Ping
author_sort Omosun, Yusuf O.
collection PubMed
description The role of killer cell immunoglobulin-like receptors (KIRs) in the transmission of HIV-1 has not been extensively studied. Here, we investigated the association of KIR gene content polymorphisms with perinatal HIV-1 transmission. The KIR gene family comprising 16 genes was genotyped in 313 HIV-1 positive Kenyan mothers paired with their infants. Gene content polymorphisms were presented as presence of individual KIR genes, haplotypes, genotypes and KIR gene concordance. The genetic data were analyzed for associations with perinatal transmission of HIV. There was no association of infant KIR genes with perinatal HIV-1 transmission. After adjustment for gravidity, viral load, and CD4 cell count, there was evidence of an association between reduction in perinatal HIV-1 transmission and the maternal individual KIR genes KIR2DL2 (adjusted OR = 0.50; 95% CI: 0.24–1.02, P = 0.06), KIR2DL5 (adjusted OR = 0.47; 95% CI: 0.23–0.95, P = 0.04) and KIR2DS5 (adjusted OR = 0.39; 95% CI: 0.18–0.80, P = 0.01). Furthermore, these maternal KIR genes were only significantly associated with reduction in perinatal HIV transmission in women with CD4 cell count ≥ 350 cells/ μl and viral load <10000 copies/ml. Concordance analysis showed that when both mother and child had KIR2DS2, there was less likelihood of perinatal HIV-1 transmission (adjusted OR = 0.44; 95% CI: 0.20–0.96, P = 0.039). In conclusion, the maternal KIR genes KIR2DL2, KIR2DL5, KIR2DS5, and KIR2DS2 were associated with reduction of HIV-1 transmission from mother to child. Furthermore, maternal immune status is an important factor in the association of KIR with perinatal HIV transmission.
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spelling pubmed-57796962018-02-08 Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1 Omosun, Yusuf O. Blackstock, Anna J. Williamson, John van Eijk, Anne Maria Ayisi, John Otieno, Juliana Lal, Renu B. ter Kuile, Feiko O. Slutsker, Laurence Shi, Ya Ping PLoS One Research Article The role of killer cell immunoglobulin-like receptors (KIRs) in the transmission of HIV-1 has not been extensively studied. Here, we investigated the association of KIR gene content polymorphisms with perinatal HIV-1 transmission. The KIR gene family comprising 16 genes was genotyped in 313 HIV-1 positive Kenyan mothers paired with their infants. Gene content polymorphisms were presented as presence of individual KIR genes, haplotypes, genotypes and KIR gene concordance. The genetic data were analyzed for associations with perinatal transmission of HIV. There was no association of infant KIR genes with perinatal HIV-1 transmission. After adjustment for gravidity, viral load, and CD4 cell count, there was evidence of an association between reduction in perinatal HIV-1 transmission and the maternal individual KIR genes KIR2DL2 (adjusted OR = 0.50; 95% CI: 0.24–1.02, P = 0.06), KIR2DL5 (adjusted OR = 0.47; 95% CI: 0.23–0.95, P = 0.04) and KIR2DS5 (adjusted OR = 0.39; 95% CI: 0.18–0.80, P = 0.01). Furthermore, these maternal KIR genes were only significantly associated with reduction in perinatal HIV transmission in women with CD4 cell count ≥ 350 cells/ μl and viral load <10000 copies/ml. Concordance analysis showed that when both mother and child had KIR2DS2, there was less likelihood of perinatal HIV-1 transmission (adjusted OR = 0.44; 95% CI: 0.20–0.96, P = 0.039). In conclusion, the maternal KIR genes KIR2DL2, KIR2DL5, KIR2DS5, and KIR2DS2 were associated with reduction of HIV-1 transmission from mother to child. Furthermore, maternal immune status is an important factor in the association of KIR with perinatal HIV transmission. Public Library of Science 2018-01-23 /pmc/articles/PMC5779696/ /pubmed/29360870 http://dx.doi.org/10.1371/journal.pone.0191733 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Omosun, Yusuf O.
Blackstock, Anna J.
Williamson, John
van Eijk, Anne Maria
Ayisi, John
Otieno, Juliana
Lal, Renu B.
ter Kuile, Feiko O.
Slutsker, Laurence
Shi, Ya Ping
Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title_full Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title_fullStr Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title_full_unstemmed Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title_short Association of maternal KIR gene content polymorphisms with reduction in perinatal transmission of HIV-1
title_sort association of maternal kir gene content polymorphisms with reduction in perinatal transmission of hiv-1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779696/
https://www.ncbi.nlm.nih.gov/pubmed/29360870
http://dx.doi.org/10.1371/journal.pone.0191733
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