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Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone

2-Pyrrolidone is a valuable bulk chemical with myriad applications as a solvent, polymer precursor and active pharmaceutical intermediate. A novel 2-pyrrolidone synthase, ORF27, from Streptomyces aizunensis was identified to catalyze the ring closing dehydration of γ-aminobutyrate. ORF27's tend...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingwei, Kao, Emily, Wang, George, Baidoo, Edward E.K., Chen, Matthew, Keasling, Jay. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779725/ https://www.ncbi.nlm.nih.gov/pubmed/29468109 http://dx.doi.org/10.1016/j.meteno.2015.11.001

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