Cargando…

Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review

Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed–Sternberg cells. Adenocarcinoma is the most frequent pathological type of stomach cancer. Improved survival in HL patients leads to the development of secondary malignancies. However...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Hongying, Wei, Liyan, Hao, Lumei, Li, Xuemei, Wang, Lei, Yuan, Chenglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779740/
https://www.ncbi.nlm.nih.gov/pubmed/29504971
http://dx.doi.org/10.1097/MD.0000000000009484
_version_ 1783294600442544128
author Wu, Hongying
Wei, Liyan
Hao, Lumei
Li, Xuemei
Wang, Lei
Yuan, Chenglu
author_facet Wu, Hongying
Wei, Liyan
Hao, Lumei
Li, Xuemei
Wang, Lei
Yuan, Chenglu
author_sort Wu, Hongying
collection PubMed
description Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed–Sternberg cells. Adenocarcinoma is the most frequent pathological type of stomach cancer. Improved survival in HL patients leads to the development of secondary malignancies. However, synchronous occurrence of these 2 malignancies is extremely rare. Here, we present a 45-year-old male complaining of a lymph node mass in the neck, without any abdominal symptoms, diagnosed as HL and gastric adenocarcinoma with hepatitis B carrier status. We treated the patient with 8 courses of pirarubicin bleomycin, vincristine, and dacarbazine (modified ABVD), and 4 courses of capecitabine therapy concurrently along with oral entecavir, as the patient survived longer than 20 months. The prognosis of multiple primary malignancies is poor because therapy is difficult, without a standard treatment. The frequency of multiple primary malignancies is increasing in recent years, and second malignancies in patients with cancer should be taken into consideration.
format Online
Article
Text
id pubmed-5779740
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-57797402018-02-05 Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review Wu, Hongying Wei, Liyan Hao, Lumei Li, Xuemei Wang, Lei Yuan, Chenglu Medicine (Baltimore) 4800 Hodgkin lymphoma (HL) is a lymphoproliferative disease arising in the lymphoid tissue, which is characterized by Reed–Sternberg cells. Adenocarcinoma is the most frequent pathological type of stomach cancer. Improved survival in HL patients leads to the development of secondary malignancies. However, synchronous occurrence of these 2 malignancies is extremely rare. Here, we present a 45-year-old male complaining of a lymph node mass in the neck, without any abdominal symptoms, diagnosed as HL and gastric adenocarcinoma with hepatitis B carrier status. We treated the patient with 8 courses of pirarubicin bleomycin, vincristine, and dacarbazine (modified ABVD), and 4 courses of capecitabine therapy concurrently along with oral entecavir, as the patient survived longer than 20 months. The prognosis of multiple primary malignancies is poor because therapy is difficult, without a standard treatment. The frequency of multiple primary malignancies is increasing in recent years, and second malignancies in patients with cancer should be taken into consideration. Wolters Kluwer Health 2018-01-19 /pmc/articles/PMC5779740/ /pubmed/29504971 http://dx.doi.org/10.1097/MD.0000000000009484 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4800
Wu, Hongying
Wei, Liyan
Hao, Lumei
Li, Xuemei
Wang, Lei
Yuan, Chenglu
Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title_full Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title_fullStr Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title_full_unstemmed Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title_short Synchronous Hodgkin lymphoma and gastric adenocarcinoma: A rare case report and literature review
title_sort synchronous hodgkin lymphoma and gastric adenocarcinoma: a rare case report and literature review
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779740/
https://www.ncbi.nlm.nih.gov/pubmed/29504971
http://dx.doi.org/10.1097/MD.0000000000009484
work_keys_str_mv AT wuhongying synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview
AT weiliyan synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview
AT haolumei synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview
AT lixuemei synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview
AT wanglei synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview
AT yuanchenglu synchronoushodgkinlymphomaandgastricadenocarcinomaararecasereportandliteraturereview