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Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (H...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779759/ https://www.ncbi.nlm.nih.gov/pubmed/29504990 http://dx.doi.org/10.1097/MD.0000000000009617 |
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author | Wei, Wei Xu, Bin Wang, Yan Wu, Chen Jiang, Jingting Wu, Changping |
author_facet | Wei, Wei Xu, Bin Wang, Yan Wu, Chen Jiang, Jingting Wu, Changping |
author_sort | Wei, Wei |
collection | PubMed |
description | BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. RESULTS: A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83–2.80, Z = 7.51, P < .001). CONCLUSION: The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis. |
format | Online Article Text |
id | pubmed-5779759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57797592018-02-05 Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis Wei, Wei Xu, Bin Wang, Yan Wu, Chen Jiang, Jingting Wu, Changping Medicine (Baltimore) 5700 BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. RESULTS: A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83–2.80, Z = 7.51, P < .001). CONCLUSION: The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis. Wolters Kluwer Health 2018-01-19 /pmc/articles/PMC5779759/ /pubmed/29504990 http://dx.doi.org/10.1097/MD.0000000000009617 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5700 Wei, Wei Xu, Bin Wang, Yan Wu, Chen Jiang, Jingting Wu, Changping Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title | Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title_full | Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title_fullStr | Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title_full_unstemmed | Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title_short | Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis |
title_sort | prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: a meta-analysis |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779759/ https://www.ncbi.nlm.nih.gov/pubmed/29504990 http://dx.doi.org/10.1097/MD.0000000000009617 |
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