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Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis

BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (H...

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Autores principales: Wei, Wei, Xu, Bin, Wang, Yan, Wu, Chen, Jiang, Jingting, Wu, Changping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779759/
https://www.ncbi.nlm.nih.gov/pubmed/29504990
http://dx.doi.org/10.1097/MD.0000000000009617
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author Wei, Wei
Xu, Bin
Wang, Yan
Wu, Chen
Jiang, Jingting
Wu, Changping
author_facet Wei, Wei
Xu, Bin
Wang, Yan
Wu, Chen
Jiang, Jingting
Wu, Changping
author_sort Wei, Wei
collection PubMed
description BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. RESULTS: A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83–2.80, Z = 7.51, P < .001). CONCLUSION: The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis.
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spelling pubmed-57797592018-02-05 Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis Wei, Wei Xu, Bin Wang, Yan Wu, Chen Jiang, Jingting Wu, Changping Medicine (Baltimore) 5700 BACKGROUND: The prognostic significance of circulating soluble programmed death ligand-1 (sPD-L1) in patients with solid tumors remains unclear. We performed a meta-analysis to address this issue. METHODS: Several electronic databases were searched from January 1970 to May 2017. The hazard ratios (HRs) and 95% confidence interval (95% CI) were calculated to determine the relationship between the level of soluble PD-L1 in peripheral blood and patient overall survival. RESULTS: A total of 1040 patients with solid tumors from 8 eligible studies were included in the present meta-analysis. The pooled HR suggested that a high level of soluble PD-L1 (sPD-L1) in peripheral blood was significantly correlated with a worse overall survival (HR = 2.26, 95% 1.83–2.80, Z = 7.51, P < .001). CONCLUSION: The present meta-analysis demonstrated that a high level of soluble PD-L1 in peripheral blood significantly predicts poor prognosis in patients with solid tumors, suggesting that high level of sPD-L1 may serve as a predictive biomarker for poor prognosis. Wolters Kluwer Health 2018-01-19 /pmc/articles/PMC5779759/ /pubmed/29504990 http://dx.doi.org/10.1097/MD.0000000000009617 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5700
Wei, Wei
Xu, Bin
Wang, Yan
Wu, Chen
Jiang, Jingting
Wu, Changping
Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title_full Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title_fullStr Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title_full_unstemmed Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title_short Prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: A meta-analysis
title_sort prognostic significance of circulating soluble programmed death ligand-1 in patients with solid tumors: a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779759/
https://www.ncbi.nlm.nih.gov/pubmed/29504990
http://dx.doi.org/10.1097/MD.0000000000009617
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