Cargando…

Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study

Please cite this paper as: Higa et al. (2012) Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses 6(4), 299–303. Background  An influenza outbreak might result in disruption of services at acute care se...

Descripción completa

Detalles Bibliográficos
Autores principales: Higa, Futoshi, Tateyama, Masao, Tomishima, Miyuki, Mukatake, Sakiko, Yamashiro, Tsuyoshi, Owan, Tomoko, Haranaga, Shusaku, Fujita, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779803/
https://www.ncbi.nlm.nih.gov/pubmed/22118572
http://dx.doi.org/10.1111/j.1750-2659.2011.00311.x
_version_ 1783294616303304704
author Higa, Futoshi
Tateyama, Masao
Tomishima, Miyuki
Mukatake, Sakiko
Yamashiro, Tsuyoshi
Owan, Tomoko
Haranaga, Shusaku
Fujita, Jiro
author_facet Higa, Futoshi
Tateyama, Masao
Tomishima, Miyuki
Mukatake, Sakiko
Yamashiro, Tsuyoshi
Owan, Tomoko
Haranaga, Shusaku
Fujita, Jiro
author_sort Higa, Futoshi
collection PubMed
description Please cite this paper as: Higa et al. (2012) Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses 6(4), 299–303. Background  An influenza outbreak might result in disruption of services at acute care setting hospitals. Objectives  In this study, we retrospectively evaluated the use of neuraminidase inhibitor chemoprophylaxis for prevention of nosocomial spread of influenza in a university hospital. Patients/Methods  During the 3‐year study period, 202 index cases of influenza [30 hospitalized patients and 172 healthcare workers (HCW)] and 762 individuals who had had close contact with the index cases (248 hospitalized patients and 514 HCW) were identified. Of these contacts, 416 received neuraminidase inhibitor chemoprophylaxis. Results  When both the index cases and the close contacts were hospitalized patients, the incidence of influenza was lower among the close contacts who received chemoprophylaxis than among those who did not (odds ratio, 0·07; confidence interval, 0·01–0·49; P = 0·012). In contrast, when the index cases were HCW, the incidence of influenza was not different between close contacts who did or did not receive chemoprophylaxis. Conclusions  This study suggests that chemoprophylaxis might be useful to prevent nosocomial spread of infection between hospitalized patients.
format Online
Article
Text
id pubmed-5779803
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-57798032018-01-31 Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study Higa, Futoshi Tateyama, Masao Tomishima, Miyuki Mukatake, Sakiko Yamashiro, Tsuyoshi Owan, Tomoko Haranaga, Shusaku Fujita, Jiro Influenza Other Respir Viruses Original Articles Please cite this paper as: Higa et al. (2012) Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses 6(4), 299–303. Background  An influenza outbreak might result in disruption of services at acute care setting hospitals. Objectives  In this study, we retrospectively evaluated the use of neuraminidase inhibitor chemoprophylaxis for prevention of nosocomial spread of influenza in a university hospital. Patients/Methods  During the 3‐year study period, 202 index cases of influenza [30 hospitalized patients and 172 healthcare workers (HCW)] and 762 individuals who had had close contact with the index cases (248 hospitalized patients and 514 HCW) were identified. Of these contacts, 416 received neuraminidase inhibitor chemoprophylaxis. Results  When both the index cases and the close contacts were hospitalized patients, the incidence of influenza was lower among the close contacts who received chemoprophylaxis than among those who did not (odds ratio, 0·07; confidence interval, 0·01–0·49; P = 0·012). In contrast, when the index cases were HCW, the incidence of influenza was not different between close contacts who did or did not receive chemoprophylaxis. Conclusions  This study suggests that chemoprophylaxis might be useful to prevent nosocomial spread of infection between hospitalized patients. Blackwell Publishing Ltd 2011-11-26 2012-07 /pmc/articles/PMC5779803/ /pubmed/22118572 http://dx.doi.org/10.1111/j.1750-2659.2011.00311.x Text en © 2011 Blackwell Publishing Ltd
spellingShingle Original Articles
Higa, Futoshi
Tateyama, Masao
Tomishima, Miyuki
Mukatake, Sakiko
Yamashiro, Tsuyoshi
Owan, Tomoko
Haranaga, Shusaku
Fujita, Jiro
Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title_full Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title_fullStr Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title_full_unstemmed Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title_short Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
title_sort role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779803/
https://www.ncbi.nlm.nih.gov/pubmed/22118572
http://dx.doi.org/10.1111/j.1750-2659.2011.00311.x
work_keys_str_mv AT higafutoshi roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT tateyamamasao roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT tomishimamiyuki roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT mukatakesakiko roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT yamashirotsuyoshi roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT owantomoko roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT haranagashusaku roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy
AT fujitajiro roleofneuraminidaseinhibitorchemoprophylaxisincontrollingnosocomialinfluenzaanobservationalstudy