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Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis

Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein-coding gene ribosomal protein S6 kinase B-2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging an...

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Autores principales: Hao, Xiaoyan, Du, Yufeng, Qian, Li, Li, Dan, Liu, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779893/
https://www.ncbi.nlm.nih.gov/pubmed/28944926
http://dx.doi.org/10.3892/mmr.2017.7607
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author Hao, Xiaoyan
Du, Yufeng
Qian, Li
Li, Dan
Liu, Xuejun
author_facet Hao, Xiaoyan
Du, Yufeng
Qian, Li
Li, Dan
Liu, Xuejun
author_sort Hao, Xiaoyan
collection PubMed
description Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein-coding gene ribosomal protein S6 kinase B-2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging and idiopathic pulmonary fibrosis (IPF), due to its activation by growth factors and regulation by the protein kinase mTOR signaling pathway. The results of the present study indicated that the expression of AP003419.16 increased significantly in patients with IPF, whereas its adjacent gene ribosomal protein S6 kinase B-2 increased simultaneously. AP003419.16 expression may be used to predict an increased risk of aging-associated IPF. The present study provided a molecular hypothesis of IPF occurrence in the aging process, in addition to novel molecular targets for the clinical treatment of IPF.
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spelling pubmed-57798932018-02-12 Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis Hao, Xiaoyan Du, Yufeng Qian, Li Li, Dan Liu, Xuejun Mol Med Rep Articles Long noncoding RNAs (lncRNAs) are able to regulate adjacent genes and thus participate in the incidence in the present study has identified lncRNA AP003419.16, adjacent to the protein-coding gene ribosomal protein S6 kinase B-2 (RPS6KB2). RPS6KB2 is believed to be involved in the process of aging and idiopathic pulmonary fibrosis (IPF), due to its activation by growth factors and regulation by the protein kinase mTOR signaling pathway. The results of the present study indicated that the expression of AP003419.16 increased significantly in patients with IPF, whereas its adjacent gene ribosomal protein S6 kinase B-2 increased simultaneously. AP003419.16 expression may be used to predict an increased risk of aging-associated IPF. The present study provided a molecular hypothesis of IPF occurrence in the aging process, in addition to novel molecular targets for the clinical treatment of IPF. D.A. Spandidos 2017-12 2017-09-25 /pmc/articles/PMC5779893/ /pubmed/28944926 http://dx.doi.org/10.3892/mmr.2017.7607 Text en Copyright: © Hao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Hao, Xiaoyan
Du, Yufeng
Qian, Li
Li, Dan
Liu, Xuejun
Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title_full Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title_fullStr Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title_full_unstemmed Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title_short Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
title_sort upregulation of long noncoding rna ap003419.16 predicts high risk of aging-associated idiopathic pulmonary fibrosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779893/
https://www.ncbi.nlm.nih.gov/pubmed/28944926
http://dx.doi.org/10.3892/mmr.2017.7607
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