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Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques

Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investiga...

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Autores principales: Liu, Tiantian, Liu, Hengfang, Feng, Li, Xiao, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779976/
https://www.ncbi.nlm.nih.gov/pubmed/28990089
http://dx.doi.org/10.3892/mmr.2017.7694
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author Liu, Tiantian
Liu, Hengfang
Feng, Li
Xiao, Bo
author_facet Liu, Tiantian
Liu, Hengfang
Feng, Li
Xiao, Bo
author_sort Liu, Tiantian
collection PubMed
description Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investigated the association between plaque vulnerable and inflammatory biomarkers using blood and plaque specimens. Carotid plaque specimens were obtained from 80 patients following stroke, 14 patients suffering from transient ischaemic attack and 17 asymptomatic patients that underwent carotid endarterectomy. To assess changes in plaque characteristics at histological levels, plaques were categorized by the time between the latest ischemic stroke and surgical intervention within 30, 30–90, 90–180 and over 180 days following stroke. Serum levels of inflammatory biomarkers interleukin (IL)-6, IL-10 and kinin B1 receptor (B1R) were measured by ELISA. Histological assessment of plaque was used to evaluate the plaque stability, progression and the inflammatory biomarker levels. Comparisons of histological characteristics demonstrated that plaques revealed an unstable phenotype following stroke within 30, 30–90 days and then remodeled into more stable plaques following stroke at 90–180 and over 180 days. By comparing the serum levels of inflammatory biomarkers, it was observed that IL-6 and B1R levels tended to decline whereas IL-10 levels increased in stroke patients from <30 days to over 180 days. Immunohistochemical analysis of IL-6, IL-10 and B1R demonstrated similar alterations in serum levels. Correlation analyses revealed that only B1R serum level was significantly correlated with histological level in patients with carotid atherosclerosis. The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis.
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spelling pubmed-57799762018-02-12 Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques Liu, Tiantian Liu, Hengfang Feng, Li Xiao, Bo Mol Med Rep Articles Stroke caused by atherosclerosis remains a leading cause of morbidity and mortality worldwide, associated with carotid plaque rupture and inflammation progression. However, the inflammatory biomarkers which aid in predicting the future course of plaques are less detailed. The present study investigated the association between plaque vulnerable and inflammatory biomarkers using blood and plaque specimens. Carotid plaque specimens were obtained from 80 patients following stroke, 14 patients suffering from transient ischaemic attack and 17 asymptomatic patients that underwent carotid endarterectomy. To assess changes in plaque characteristics at histological levels, plaques were categorized by the time between the latest ischemic stroke and surgical intervention within 30, 30–90, 90–180 and over 180 days following stroke. Serum levels of inflammatory biomarkers interleukin (IL)-6, IL-10 and kinin B1 receptor (B1R) were measured by ELISA. Histological assessment of plaque was used to evaluate the plaque stability, progression and the inflammatory biomarker levels. Comparisons of histological characteristics demonstrated that plaques revealed an unstable phenotype following stroke within 30, 30–90 days and then remodeled into more stable plaques following stroke at 90–180 and over 180 days. By comparing the serum levels of inflammatory biomarkers, it was observed that IL-6 and B1R levels tended to decline whereas IL-10 levels increased in stroke patients from <30 days to over 180 days. Immunohistochemical analysis of IL-6, IL-10 and B1R demonstrated similar alterations in serum levels. Correlation analyses revealed that only B1R serum level was significantly correlated with histological level in patients with carotid atherosclerosis. The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis. D.A. Spandidos 2017-12 2017-10-03 /pmc/articles/PMC5779976/ /pubmed/28990089 http://dx.doi.org/10.3892/mmr.2017.7694 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Liu, Tiantian
Liu, Hengfang
Feng, Li
Xiao, Bo
Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title_full Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title_fullStr Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title_full_unstemmed Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title_short Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
title_sort kinin b1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779976/
https://www.ncbi.nlm.nih.gov/pubmed/28990089
http://dx.doi.org/10.3892/mmr.2017.7694
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