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Semi-random mutagenesis profile of BCR-ABL during imatinib resistance acquirement in K562 cells

Although imatinib is effective in chronic myeloid leukemia treatment, imatinib resistance due to the T315I mutation and/or other mutations is a challenge to be overcome. However, how DNA mutation occurs, particularly the T315I mutation, remains unclear. In the current study, the mutagenesis of BCR-A...

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Detalles Bibliográficos
Autores principales:	Dong, Yan, Gao, Xiaotong, Zhao, Yingxin, Wei, Mengying, Xu, Lingmin, Yang, Guodong, Liu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779997/ https://www.ncbi.nlm.nih.gov/pubmed/29152650 http://dx.doi.org/10.3892/mmr.2017.7835

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