Cargando…
Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4
Neuroblastoma is the most common extracranial solid childhood tumor. Despite the availability of advanced multimodal therapy, high-risk patients still have low survival rates. p21-activated kinase 4 (PAK4) has been shown to regulate many cellular processes in cancer cells, including migration, polar...
Autores principales: | Li, Zhiheng, Li, Xiaolu, Xu, Lixiao, Tao, Yanfang, Yang, Chun, Chen, Xiaolan, Fang, Fang, Wu, Yi, Ding, Xin, Zhao, He, Li, Mei, Qian, Guanghui, Xu, Yunyun, Ren, Junli, Du, Weiwei, Wang, Jian, Lu, Jun, Hu, Shaoyan, Pan, Jian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780023/ https://www.ncbi.nlm.nih.gov/pubmed/29048629 http://dx.doi.org/10.3892/or.2017.5989 |
Ejemplares similares
-
The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells
por: Li, Zhiheng, et al.
Publicado: (2020) -
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models
por: Pitts, Todd M., et al.
Publicado: (2013) -
Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency
por: Vargas, Benni, et al.
Publicado: (2023) -
Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer
por: Bradshaw-Pierce, Erica Lynn, et al.
Publicado: (2013) -
PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor Activity in Neuroblastoma by Repressing Expression of MYCN or c-Myc
por: Li, Zhiheng, et al.
Publicado: (2020)