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Endosomal Rab cycles regulate Parkin-mediated mitophagy

Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autoph...

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Detalles Bibliográficos
Autores principales:	Yamano, Koji, Wang, Chunxin, Sarraf, Shireen A, Münch, Christian, Kikuchi, Reika, Noda, Nobuo N, Hizukuri, Yohei, Kanemaki, Masato T, Harper, Wade, Tanaka, Keiji, Matsuda, Noriyuki, Youle, Richard J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780041/ https://www.ncbi.nlm.nih.gov/pubmed/29360040 http://dx.doi.org/10.7554/eLife.31326

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