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Human subthalamic nucleus activity during non-motor decision making

Recent studies have implicated the subthalamic nucleus (STN) in decisions that involve inhibiting movements. Many of the decisions that we make in our daily lives, however, do not involve any motor actions. We studied non-motor decision making by recording intraoperative STN and prefrontal cortex (P...

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Autores principales: Zavala, Baltazar A, Jang, Anthony I, Zaghloul, Kareem A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780045/
https://www.ncbi.nlm.nih.gov/pubmed/29243587
http://dx.doi.org/10.7554/eLife.31007
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author Zavala, Baltazar A
Jang, Anthony I
Zaghloul, Kareem A
author_facet Zavala, Baltazar A
Jang, Anthony I
Zaghloul, Kareem A
author_sort Zavala, Baltazar A
collection PubMed
description Recent studies have implicated the subthalamic nucleus (STN) in decisions that involve inhibiting movements. Many of the decisions that we make in our daily lives, however, do not involve any motor actions. We studied non-motor decision making by recording intraoperative STN and prefrontal cortex (PFC) electrophysiology as participants perform a novel task that required them to decide whether to encode items into working memory. During all encoding trials, beta band (15–30 Hz) activity decreased in the STN and PFC, and this decrease was progressively enhanced as more items were stored into working memory. Crucially, the STN and lateral PFC beta decrease was significantly attenuated during the trials in which participants were instructed not to encode the presented stimulus. These changes were associated with increase lateral PFC-STN coherence and altered STN neuronal spiking. Our results shed light on why states of altered basal ganglia activity disrupt both motor function and cognition.
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spelling pubmed-57800452018-01-25 Human subthalamic nucleus activity during non-motor decision making Zavala, Baltazar A Jang, Anthony I Zaghloul, Kareem A eLife Neuroscience Recent studies have implicated the subthalamic nucleus (STN) in decisions that involve inhibiting movements. Many of the decisions that we make in our daily lives, however, do not involve any motor actions. We studied non-motor decision making by recording intraoperative STN and prefrontal cortex (PFC) electrophysiology as participants perform a novel task that required them to decide whether to encode items into working memory. During all encoding trials, beta band (15–30 Hz) activity decreased in the STN and PFC, and this decrease was progressively enhanced as more items were stored into working memory. Crucially, the STN and lateral PFC beta decrease was significantly attenuated during the trials in which participants were instructed not to encode the presented stimulus. These changes were associated with increase lateral PFC-STN coherence and altered STN neuronal spiking. Our results shed light on why states of altered basal ganglia activity disrupt both motor function and cognition. eLife Sciences Publications, Ltd 2017-12-15 /pmc/articles/PMC5780045/ /pubmed/29243587 http://dx.doi.org/10.7554/eLife.31007 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Neuroscience
Zavala, Baltazar A
Jang, Anthony I
Zaghloul, Kareem A
Human subthalamic nucleus activity during non-motor decision making
title Human subthalamic nucleus activity during non-motor decision making
title_full Human subthalamic nucleus activity during non-motor decision making
title_fullStr Human subthalamic nucleus activity during non-motor decision making
title_full_unstemmed Human subthalamic nucleus activity during non-motor decision making
title_short Human subthalamic nucleus activity during non-motor decision making
title_sort human subthalamic nucleus activity during non-motor decision making
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780045/
https://www.ncbi.nlm.nih.gov/pubmed/29243587
http://dx.doi.org/10.7554/eLife.31007
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