Cargando…

DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53-deficient pancreatic cancer cells

The aberrant expression of DNA methyltransferases (DNMTs) has been considered to be associated with pancreatic carcinogenesis and progression. DNMT3a is widely involved in cell proliferation and cell cycle progression in pancreatic ductal adenocarcinoma (PDAC) cells. However, its regulation of chemo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jing, Wei, Song, Na, Liu, Yunpeng, Qu, Xiujuan, Hou, Kezuo, Yang, Xianghong, Che, Xiaofang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780073/ https://www.ncbi.nlm.nih.gov/pubmed/29115606 http://dx.doi.org/10.3892/mmr.2017.7923

Ejemplares similares

A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells
por: Song, Na, et al.
Publicado: (2017)

An Immune Cell Signature Is Associated With Disease-Free Survival and Adjuvant Chemosensitivity of Patients With Resectable Gastric Cancer
por: Yan, Hongfei, et al.
Publicado: (2021)

Assessment of Nine Driver Gene Mutations in Surgically Resected Samples from Patients with Non-Small-Cell Lung Cancer
por: Wang, Shuo, et al.
Publicado: (2020)

CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer
por: Hsieh, Chi-Che, et al.
Publicado: (2022)

MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma
por: Li, Ce, et al.
Publicado: (2018)

Distinct prognostic values of programmed death-ligand 1 and programmed cell death protein 1 in lung adenocarcinoma and squamous cell carcinoma patients
por: Wang, Shuo, et al.
Publicado: (2021)

microRNA-569 inhibits tumor metastasis in pancreatic cancer by directly targeting NUSAP1
por: Guo, Xiaohui, et al.
Publicado: (2022)

BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1
por: Li, Lemin, et al.
Publicado: (2023)

Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
por: Gong, Jing, et al.
Publicado: (2020)

Comparative Analysis and in vitro Experiments of Signatures and Prognostic Value of Immune Checkpoint Genes in Colorectal Cancer
por: Ma, Rui, et al.
Publicado: (2021)

Retracted: Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells
por: Gong, Jing, et al.
Publicado: (2023)

Knockdown of G‐protein‐signaling modulator 2 promotes metastasis of non‐small‐cell lung cancer by inducing the expression of Snail
por: Deng, Mingming, et al.
Publicado: (2020)

Clinical significance of pAkt and pErk1/2 expression in early-stage breast cancer patients treated with anthracycline-based adjuvant chemotherapy
por: LIU, WENJUAN, et al.
Publicado: (2015)

Gemcitabine and oxaliplatin (GEMOX) in gemcitabine refractory advanced pancreatic adenocarcinoma: a phase II study
por: Demols, A, et al.
Publicado: (2006)

M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer
por: Cao, Lili, et al.
Publicado: (2019)

NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer
por: Yan, Hongfei, et al.
Publicado: (2019)

Localization of GPSM2 in the Nucleus of Invasive Breast Cancer Cells Indicates a Poor Prognosis
por: Deng, Mingming, et al.
Publicado: (2020)

Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
por: Fang, Wanxia, et al.
Publicado: (2020)

Correction to: Sur-X, a novel peptide, kills colorectal cancer cells by targeting survivin-XIAP complex
por: Fang, Wanxia, et al.
Publicado: (2021)

Girdin Knockdown Increases Gemcitabine Chemosensitivity to Pancreatic Cancer by Modulating Autophagy
por: Wang, Sheng, et al.
Publicado: (2021)

Combination of PI3K/Akt Pathway Inhibition and Plk1 Depletion Can Enhance Chemosensitivity to Gemcitabine in Pancreatic Carcinoma
por: Mao, Yonghuan, et al.
Publicado: (2018)

AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes
por: Shan, Baocong, et al.
Publicado: (2020)

Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
por: Duong, Hong-Quan, et al.
Publicado: (2013)

MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells
por: Dong, Qian, et al.
Publicado: (2016)

Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors
por: ZHAO, LEI, et al.
Publicado: (2015)

5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients
por: Zhang, Min, et al.
Publicado: (2020)

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer
por: Zhang, Xianbin, et al.
Publicado: (2019)

MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression
por: Duan, Jiangman, et al.
Publicado: (2017)

miR-1323 Promotes Cell Migration in Lung Adenocarcinoma by Targeting Cbl-b and Is an Early Prognostic Biomarker
por: Zhao, Huan, et al.
Publicado: (2020)

Gemcitabine: An Alternative Treatment for Oxaliplatin-Resistant Colorectal Cancer
por: Chocry, Mathieu, et al.
Publicado: (2022)

Metabolic Phenotyping Predicts Gemcitabine and Cisplatin Chemosensitivity in Patients With Cholangiocarcinoma
por: Suksawat, Manida, et al.
Publicado: (2022)

LY-294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF-1α pathway
por: Xu, Ruyue, et al.
Publicado: (2021)

Autophagy deficiency downregulates O(6)methylguanine-DNA methyltransferase and increases chemosensitivity of liver cancer cells
por: Hou, Xiaojuan, et al.
Publicado: (2021)

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine
por: Goss, Kelli L, et al.
Publicado: (2017)

Cbl-b predicts postoperative survival in patients with resectable pancreatic ductal adenocarcinoma
por: Dong, Qian, et al.
Publicado: (2017)

Cisplatin/gemcitabine or oxaliplatin/gemcitabine in the treatment of advanced biliary tract cancer: a systematic review
por: Fiteni, Frédéric, et al.
Publicado: (2014)

Preoperative Gemcitabine and Oxaliplatin in a Patient with Ovarian Metastasis from Pancreatic Cystadenocarcinoma
por: Di Marco, Mariacristina, et al.
Publicado: (2012)

Lipocalin 2 may be a key factor regulating the chemosensitivity of pancreatic cancer to gemcitabine
por: Zhang, He, et al.
Publicado: (2022)

Suppression of 14-3-3ζ in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine
por: Kittirat, Yingpinyapat, et al.
Publicado: (2018)

Transcatheter arterial chemoembolization with gemcitabine and oxaliplatin for the treatment of advanced biliary tract cancer
por: Zhao, Qing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6r3i5n0otonsmv24rqfknsceni