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Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center

OBJECTIVE: This study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. METHODS: This study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those hav...

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Autores principales: Kim, Woo Jeng, Han, Young Sin, Ko, Hyun Sun, Park, In Yang, Shin, Jong Chul, Wie, Jeong Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780323/
https://www.ncbi.nlm.nih.gov/pubmed/29372144
http://dx.doi.org/10.5468/ogs.2018.61.1.7
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author Kim, Woo Jeng
Han, Young Sin
Ko, Hyun Sun
Park, In Yang
Shin, Jong Chul
Wie, Jeong Ha
author_facet Kim, Woo Jeng
Han, Young Sin
Ko, Hyun Sun
Park, In Yang
Shin, Jong Chul
Wie, Jeong Ha
author_sort Kim, Woo Jeng
collection PubMed
description OBJECTIVE: This study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. METHODS: This study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those having a singleton SGA neonate born between 29 and 34 complete gestational weeks. The neonates born after 32 weeks of gestation were divided into subgroups. Multivariable logistic regression analysis was performed. RESULTS: A total 82 of the preterm infants met inclusion criteria; 57 (69.5%) were born after 32 weeks of gestation. There were no significant differences in terms of mechanical ventilation, seizure, intracranial hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, feeding difficulty, and neonatal mortality between infants whose mothers received ACS ant those whose mothers did not (all P>0.05). However, newborns whose mothers received ACS exhibited a significantly increased risk of developing respiratory distress syndrome (RDS) (adjusted odds ratio [aOR], 3.271; 95% confidence interval [CI], 1.038–10.305; P=0.043). In case of neonates born beyond 32 weeks of gestation, the risk of neonatal hypoglycemia was significantly higher in women receiving ACS after controlling for confounding factors (aOR, 5.832; 95% CI, 1.096–31.031; P=0.039). CONCLUSION: ACS did not improve neonatal morbidities, in SGA neonates delivered between 29 and 34 gestational weeks. Rather, ACS could increase the risk of RDS. In cases of SGA neonate delivered between 32 and 34 complete gestational weeks, the risk of hypoglycemia was significantly increased. The use of ACS in women with preterm SGA infants needs to be evaluated further, especially after 32 weeks' gestation.
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spelling pubmed-57803232018-01-25 Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center Kim, Woo Jeng Han, Young Sin Ko, Hyun Sun Park, In Yang Shin, Jong Chul Wie, Jeong Ha Obstet Gynecol Sci Original Article OBJECTIVE: This study investigated the effect of an antenatal corticosteroid (ACS) in preterm small-for-gestational-age (SGA) neonate. METHODS: This study was a retrospective cohort study. We compared women who received ACS with unexposed controls and evaluated neonatal complications among those having a singleton SGA neonate born between 29 and 34 complete gestational weeks. The neonates born after 32 weeks of gestation were divided into subgroups. Multivariable logistic regression analysis was performed. RESULTS: A total 82 of the preterm infants met inclusion criteria; 57 (69.5%) were born after 32 weeks of gestation. There were no significant differences in terms of mechanical ventilation, seizure, intracranial hemorrhage, retinopathy of prematurity, necrotizing enterocolitis, feeding difficulty, and neonatal mortality between infants whose mothers received ACS ant those whose mothers did not (all P>0.05). However, newborns whose mothers received ACS exhibited a significantly increased risk of developing respiratory distress syndrome (RDS) (adjusted odds ratio [aOR], 3.271; 95% confidence interval [CI], 1.038–10.305; P=0.043). In case of neonates born beyond 32 weeks of gestation, the risk of neonatal hypoglycemia was significantly higher in women receiving ACS after controlling for confounding factors (aOR, 5.832; 95% CI, 1.096–31.031; P=0.039). CONCLUSION: ACS did not improve neonatal morbidities, in SGA neonates delivered between 29 and 34 gestational weeks. Rather, ACS could increase the risk of RDS. In cases of SGA neonate delivered between 32 and 34 complete gestational weeks, the risk of hypoglycemia was significantly increased. The use of ACS in women with preterm SGA infants needs to be evaluated further, especially after 32 weeks' gestation. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018-01 2017-12-26 /pmc/articles/PMC5780323/ /pubmed/29372144 http://dx.doi.org/10.5468/ogs.2018.61.1.7 Text en Copyright © 2018 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Woo Jeng
Han, Young Sin
Ko, Hyun Sun
Park, In Yang
Shin, Jong Chul
Wie, Jeong Ha
Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title_full Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title_fullStr Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title_full_unstemmed Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title_short Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
title_sort antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780323/
https://www.ncbi.nlm.nih.gov/pubmed/29372144
http://dx.doi.org/10.5468/ogs.2018.61.1.7
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