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Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages
Phenolic glycolipids (PGLs) are cell wall components of a subset of pathogenic mycobacteria, with immunomodulatory properties. Here, we show that in addition, PGLs exert antibactericidal activity by limiting the production of nitric oxide synthase (iNOS) in mycobacteria-infected macrophages. PGL-med...
Autores principales: | Oldenburg, Reid, Mayau, Veronique, Prandi, Jacques, Arbues, Ainhoa, Astarie-Dequeker, Catherine, Guilhot, Christophe, Werts, Catherine, Winter, Nathalie, Demangel, Caroline |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780341/ https://www.ncbi.nlm.nih.gov/pubmed/29403489 http://dx.doi.org/10.3389/fimmu.2018.00002 |
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