Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus

A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole...

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Autores principales: Kim, Minchul, Lee, Hyekyung, Hwang, Sun-Young, Lee, Inhyung, Jung, Won Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2017
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780376/
https://www.ncbi.nlm.nih.gov/pubmed/29371812
http://dx.doi.org/10.5941/MYCO.2017.45.4.426
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author Kim, Minchul
Lee, Hyekyung
Hwang, Sun-Young
Lee, Inhyung
Jung, Won Hee
author_facet Kim, Minchul
Lee, Hyekyung
Hwang, Sun-Young
Lee, Inhyung
Jung, Won Hee
author_sort Kim, Minchul
collection PubMed
description A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C. glabrata isolated here.
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spelling pubmed-57803762018-01-25 Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus Kim, Minchul Lee, Hyekyung Hwang, Sun-Young Lee, Inhyung Jung, Won Hee Mycobiology Research Note A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C. glabrata isolated here. The Korean Society of Mycology 2017-12 2017-12-31 /pmc/articles/PMC5780376/ /pubmed/29371812 http://dx.doi.org/10.5941/MYCO.2017.45.4.426 Text en © The Korean Society of Mycology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Kim, Minchul
Lee, Hyekyung
Hwang, Sun-Young
Lee, Inhyung
Jung, Won Hee
Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title_full Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title_fullStr Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title_full_unstemmed Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title_short Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus
title_sort azole resistance caused by increased drug efflux in candida glabrata isolated from the urinary tract of a dog with diabetes mellitus
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780376/
https://www.ncbi.nlm.nih.gov/pubmed/29371812
http://dx.doi.org/10.5941/MYCO.2017.45.4.426
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