New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death

We previously synthesized new 5-thienyl-substituted 2-aminobenzamide-type HDAC1, 2 inhibitors with the (4-ethyl-2,3-dioxopiperazine-1-carboxamido) methyl group. K-560 (1a) protected against neuronal cell death in a Parkinson’s disease model by up-regulating the expression of XIAP. This finding promp...

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Detalles Bibliográficos
Autores principales: Hirata, Yoshiyuki, Sasaki, Tsutomu, Kanki, Hideaki, Choong, Chi-Jing, Nishiyama, Kumiko, Kubo, Genki, Hotei, Ayana, Taniguchi, Masahiko, Mochizuki, Hideki, Uesato, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780423/
https://www.ncbi.nlm.nih.gov/pubmed/29362442
http://dx.doi.org/10.1038/s41598-018-19664-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780423/
https://www.ncbi.nlm.nih.gov/pubmed/29362442
http://dx.doi.org/10.1038/s41598-018-19664-9

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