Lack of beta-arrestin signaling in the absence of active G proteins

G protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous biological processes. However, arrestin signaling in the collective absence of functional G proteins has never been demonstrated....

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Detalles Bibliográficos
Autores principales: Grundmann, Manuel, Merten, Nicole, Malfacini, Davide, Inoue, Asuka, Preis, Philip, Simon, Katharina, Rüttiger, Nelly, Ziegler, Nicole, Benkel, Tobias, Schmitt, Nina Katharina, Ishida, Satoru, Müller, Ines, Reher, Raphael, Kawakami, Kouki, Inoue, Ayumi, Rick, Ulrike, Kühl, Toni, Imhof, Diana, Aoki, Junken, König, Gabriele M., Hoffmann, Carsten, Gomeza, Jesus, Wess, Jürgen, Kostenis, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780443/
https://www.ncbi.nlm.nih.gov/pubmed/29362459
http://dx.doi.org/10.1038/s41467-017-02661-3

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