Cargando…

Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population

Metabolomics-genome-wide association studies (mGWAS) have uncovered many metabolic quantitative trait loci (mQTLs) influencing human metabolic individuality, though predominantly in European cohorts. By combining whole-exome sequencing with a high-resolution metabolomics profiling for a highly consa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yousri, Noha A., Fakhro, Khalid A., Robay, Amal, Rodriguez-Flores, Juan L., Mohney, Robert P., Zeriri, Hassina, Odeh, Tala, Kader, Sara Abdul, Aldous, Eman K., Thareja, Gaurav, Kumar, Manish, Al-Shakaki, Alya, Chidiac, Omar M., Mohamoud, Yasmin A., Mezey, Jason G., Malek, Joel A., Crystal, Ronald G., Suhre, Karsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780481/ https://www.ncbi.nlm.nih.gov/pubmed/29362361 http://dx.doi.org/10.1038/s41467-017-01972-9

Ejemplares similares

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population
por: O’Beirne, Sarah L., et al.
Publicado: (2018)

Novel MYO5B mutation in microvillous inclusion disease of Syrian ancestry
por: Hassan, Kamal, et al.
Publicado: (2022)

Copy number variations in the genome of the Qatari population
por: Fakhro, Khalid A., et al.
Publicado: (2015)

The Qatar genome: a population-specific tool for precision medicine in the Middle East
por: Fakhro, Khalid A, et al.
Publicado: (2016)

Genotyping-by-sequencing identifies date palm clone preference in agronomics of the State of Qatar
por: Thareja, Gaurav, et al.
Publicado: (2018)

Two hits in one: whole genome sequencing unveils LIG4 syndrome and urofacial syndrome in a case report of a child with complex phenotype
por: Fadda, Abeer, et al.
Publicado: (2016)

Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population
por: O’Beirne, Sarah L., et al.
Publicado: (2016)

Type 2 Diabetes Risk Allele Loci in the Qatari Population
por: O’Beirne, Sarah L., et al.
Publicado: (2016)

Circulating microparticles in acute diabetic Charcot foot exhibit a high content of inflammatory cytokines, and support monocyte-to-osteoclast cell induction
por: Pasquier, Jennifer, et al.
Publicado: (2017)

Retinal nerve fibre layer thinning and corneal nerve loss in patients with Bardet-Biedl syndrome
por: Belkadi, Aziz, et al.
Publicado: (2023)

Exome QTL-seq maps monogenic locus and QTLs in barley
por: Hisano, Hiroshi, et al.
Publicado: (2017)

A systematic review on the genetics of male infertility in the era of next-generation sequencing
por: Robay, Amal, et al.
Publicado: (2018)

Evidence of Recombination Suppression Blocks on the Y Chromosome of Date Palm (Phoenix dactylifera)
por: Torres, Maria F., et al.
Publicado: (2021)

Deletion of beta‐fructofuranosidase (invertase) genes is associated with sucrose content in Date Palm fruit
por: Malek, Joel A., et al.
Publicado: (2020)

Long term conservation of human metabolic phenotypes and link to heritability
por: Yousri, Noha A., et al.
Publicado: (2014)

Large Scale Metabolic Profiling identifies Novel Steroids linked to Rheumatoid Arthritis
por: Yousri, Noha A., et al.
Publicado: (2017)

The QChip1 knowledgebase and microarray for precision medicine in Qatar
por: Rodriguez-Flores, Juan L., et al.
Publicado: (2022)

Defining the landscape of metabolic dysregulations in cancer metastasis
por: Abdul Kader, Sara, et al.
Publicado: (2021)

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations
por: Rodriguez-Flores, Juan L., et al.
Publicado: (2016)

Novel subpopulations in date palm (Phoenix dactylifera) identified by population-wide organellar genome sequencing
por: Mohamoud, Yasmin A., et al.
Publicado: (2019)

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
por: Zaghlool, Shaza B., et al.
Publicado: (2020)

MetaRNA-Seq: An Interactive Tool to Browse and Annotate Metadata from RNA-Seq Studies
por: Kumar, Pankaj, et al.
Publicado: (2015)

Identification of eQTLs and sQTLs associated with meat quality in beef
por: Leal-Gutiérrez, Joel D., et al.
Publicado: (2020)

A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines
por: Al-Khelaifi, Fatima, et al.
Publicado: (2018)

Metabolomics profiling of xenobiotics in elite athletes: relevance to supplement consumption
por: Al-Khelaifi, Fatima, et al.
Publicado: (2018)

Exome Sequencing of Only Seven Qataris Identifies Potentially Deleterious Variants in the Qatari Population
por: Rodriguez-Flores, Juan L., et al.
Publicado: (2012)

QTLs maintaining grain fertility under salt stress detected by exome QTL-seq and interval mapping in barley
por: Kodama, Asuka, et al.
Publicado: (2018)

QTLs and eQTLs mapping related to citrandarins’ resistance to citrus gummosis disease
por: Lima, Rômulo P. M., et al.
Publicado: (2018)

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin
por: Xiao, Qian, et al.
Publicado: (2023)

Identification of Possible Risk Variants of Familial Strabismus Using Exome Sequencing Analysis
por: An, Joon-Yong, et al.
Publicado: (2021)

A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes
por: Guennoun, Andrea, et al.
Publicado: (2021)

A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control
por: Yousri, Noha A., et al.
Publicado: (2015)

Erratum to: A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control
por: Yousri, Noha A., et al.
Publicado: (2015)

Author Correction: Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance
por: Al-Khelaifi, Fatima, et al.
Publicado: (2020)

Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance
por: Al-Khelaifi, Fatima, et al.
Publicado: (2019)

Mapping QTLs for oil traits and eQTLs for oleosin genes in jatropha
por: Liu, Peng, et al.
Publicado: (2011)

Proteome‐wide associations with short‐ and long‐term weight loss and regain after Roux‐en‐Y gastric bypass surgery
por: Yousri, Noha A., et al.
Publicado: (2021)

Development and characterization of microsatellite primers for Triops granarius (Branchiopoda: Notostraca) using MiSeq technology
por: Ahmed, Lina, et al.
Publicado: (2022)

Linking Metabolic QTLs with Network and cis-eQTLs Controlling Biosynthetic Pathways
por: Wentzell, Adam M, et al.
Publicado: (2007)

Single-cell RNA sequencing identifies cell type-specific cis-eQTLs and co-expression QTLs
por: van der Wijst, Monique G.P., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_egnqcqei7n1mgmpci0786stojh