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Role of positron emission tomography-computed tomography in endometrial cancer

OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factor...

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Autores principales: Erdemoğlu, Evrim, Çerçi, Sevim Süreyya, Erdemoğlu, Ebru, Yalçın, Yakup, Tatar, Burak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780562/
https://www.ncbi.nlm.nih.gov/pubmed/29379661
http://dx.doi.org/10.4274/tjod.24572
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author Erdemoğlu, Evrim
Çerçi, Sevim Süreyya
Erdemoğlu, Ebru
Yalçın, Yakup
Tatar, Burak
author_facet Erdemoğlu, Evrim
Çerçi, Sevim Süreyya
Erdemoğlu, Ebru
Yalçın, Yakup
Tatar, Burak
author_sort Erdemoğlu, Evrim
collection PubMed
description OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factors in endometrial cancer. MATERIALS AND METHODS: Thirty patients with endometrial cancer underwent preoperative (18)F-FDG/PET-CT. The patients were treated with abdominal hysterectomy with bilateral salpingo-oophorectomy, and bilateral systemic pelvic lymphadenectomy was planned for all patients; paraaortic lymphadenectomy was performed in patients with intermediate and high risk. Tumor histology, grade, depth of myometrial invasion, maximum tumor diameter, lymphovascular invasion, nodal status, and ovarian/adnexal metastases were recorded. RESULTS: The mean primary tumor diameter was reported smaller in PET-CT and the effect size of PET-CT was -0.60. The kappa value was 0.06 for myometrial invasion. Pelvic lymph node metastasis was reported in 22.2% of patients in PET-CT. However, 3.7% of patients had pelvic lymph node metastasis. The kappa value for pelvic lymph node metastasis was 0.23, and sensitivity, specificity, and positive and negative predictive values were 100%, 80.7%, 16.6%, and 100%, respectively. Paraaortic lymph node metastasis in PET-CT was suspected in 10%. However, paraaortic lymph node metastasis was found in 6.7% in histopathologic analyses. The kappa value was 0.15. The sensitivity, specificity, and positive and negative predictive values of PET-CT for detecting paraaortic lymph node metastases were 100%, 93.7%, 66.6%, and 100%, respectively. Myometrial invasion and tumor diameter were the only important prognostic factors affecting SUV(max.) CONCLUSION: According to our results, PET-CT has a limited role and diagnostic efficacy in endometrial cancer. The indications of FDG/PET-CT in endometrium cancer should be studied further and revised.
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spelling pubmed-57805622018-01-29 Role of positron emission tomography-computed tomography in endometrial cancer Erdemoğlu, Evrim Çerçi, Sevim Süreyya Erdemoğlu, Ebru Yalçın, Yakup Tatar, Burak Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factors in endometrial cancer. MATERIALS AND METHODS: Thirty patients with endometrial cancer underwent preoperative (18)F-FDG/PET-CT. The patients were treated with abdominal hysterectomy with bilateral salpingo-oophorectomy, and bilateral systemic pelvic lymphadenectomy was planned for all patients; paraaortic lymphadenectomy was performed in patients with intermediate and high risk. Tumor histology, grade, depth of myometrial invasion, maximum tumor diameter, lymphovascular invasion, nodal status, and ovarian/adnexal metastases were recorded. RESULTS: The mean primary tumor diameter was reported smaller in PET-CT and the effect size of PET-CT was -0.60. The kappa value was 0.06 for myometrial invasion. Pelvic lymph node metastasis was reported in 22.2% of patients in PET-CT. However, 3.7% of patients had pelvic lymph node metastasis. The kappa value for pelvic lymph node metastasis was 0.23, and sensitivity, specificity, and positive and negative predictive values were 100%, 80.7%, 16.6%, and 100%, respectively. Paraaortic lymph node metastasis in PET-CT was suspected in 10%. However, paraaortic lymph node metastasis was found in 6.7% in histopathologic analyses. The kappa value was 0.15. The sensitivity, specificity, and positive and negative predictive values of PET-CT for detecting paraaortic lymph node metastases were 100%, 93.7%, 66.6%, and 100%, respectively. Myometrial invasion and tumor diameter were the only important prognostic factors affecting SUV(max.) CONCLUSION: According to our results, PET-CT has a limited role and diagnostic efficacy in endometrial cancer. The indications of FDG/PET-CT in endometrium cancer should be studied further and revised. Galenos Publishing 2017-12 2017-12-30 /pmc/articles/PMC5780562/ /pubmed/29379661 http://dx.doi.org/10.4274/tjod.24572 Text en ©Copyright 2017 by Turkish Society of Obstetrics and Gynecology Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Erdemoğlu, Evrim
Çerçi, Sevim Süreyya
Erdemoğlu, Ebru
Yalçın, Yakup
Tatar, Burak
Role of positron emission tomography-computed tomography in endometrial cancer
title Role of positron emission tomography-computed tomography in endometrial cancer
title_full Role of positron emission tomography-computed tomography in endometrial cancer
title_fullStr Role of positron emission tomography-computed tomography in endometrial cancer
title_full_unstemmed Role of positron emission tomography-computed tomography in endometrial cancer
title_short Role of positron emission tomography-computed tomography in endometrial cancer
title_sort role of positron emission tomography-computed tomography in endometrial cancer
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780562/
https://www.ncbi.nlm.nih.gov/pubmed/29379661
http://dx.doi.org/10.4274/tjod.24572
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