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Role of positron emission tomography-computed tomography in endometrial cancer
OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780562/ https://www.ncbi.nlm.nih.gov/pubmed/29379661 http://dx.doi.org/10.4274/tjod.24572 |
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author | Erdemoğlu, Evrim Çerçi, Sevim Süreyya Erdemoğlu, Ebru Yalçın, Yakup Tatar, Burak |
author_facet | Erdemoğlu, Evrim Çerçi, Sevim Süreyya Erdemoğlu, Ebru Yalçın, Yakup Tatar, Burak |
author_sort | Erdemoğlu, Evrim |
collection | PubMed |
description | OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factors in endometrial cancer. MATERIALS AND METHODS: Thirty patients with endometrial cancer underwent preoperative (18)F-FDG/PET-CT. The patients were treated with abdominal hysterectomy with bilateral salpingo-oophorectomy, and bilateral systemic pelvic lymphadenectomy was planned for all patients; paraaortic lymphadenectomy was performed in patients with intermediate and high risk. Tumor histology, grade, depth of myometrial invasion, maximum tumor diameter, lymphovascular invasion, nodal status, and ovarian/adnexal metastases were recorded. RESULTS: The mean primary tumor diameter was reported smaller in PET-CT and the effect size of PET-CT was -0.60. The kappa value was 0.06 for myometrial invasion. Pelvic lymph node metastasis was reported in 22.2% of patients in PET-CT. However, 3.7% of patients had pelvic lymph node metastasis. The kappa value for pelvic lymph node metastasis was 0.23, and sensitivity, specificity, and positive and negative predictive values were 100%, 80.7%, 16.6%, and 100%, respectively. Paraaortic lymph node metastasis in PET-CT was suspected in 10%. However, paraaortic lymph node metastasis was found in 6.7% in histopathologic analyses. The kappa value was 0.15. The sensitivity, specificity, and positive and negative predictive values of PET-CT for detecting paraaortic lymph node metastases were 100%, 93.7%, 66.6%, and 100%, respectively. Myometrial invasion and tumor diameter were the only important prognostic factors affecting SUV(max.) CONCLUSION: According to our results, PET-CT has a limited role and diagnostic efficacy in endometrial cancer. The indications of FDG/PET-CT in endometrium cancer should be studied further and revised. |
format | Online Article Text |
id | pubmed-5780562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-57805622018-01-29 Role of positron emission tomography-computed tomography in endometrial cancer Erdemoğlu, Evrim Çerçi, Sevim Süreyya Erdemoğlu, Ebru Yalçın, Yakup Tatar, Burak Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: The efficacy of preoperative (18)F-fluoro-D-glucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) in endometrium cancer is controversial. We examined the efficacy of PET-CT and the association between maximum standardized uptake value (SUVmax) and prognostic factors in endometrial cancer. MATERIALS AND METHODS: Thirty patients with endometrial cancer underwent preoperative (18)F-FDG/PET-CT. The patients were treated with abdominal hysterectomy with bilateral salpingo-oophorectomy, and bilateral systemic pelvic lymphadenectomy was planned for all patients; paraaortic lymphadenectomy was performed in patients with intermediate and high risk. Tumor histology, grade, depth of myometrial invasion, maximum tumor diameter, lymphovascular invasion, nodal status, and ovarian/adnexal metastases were recorded. RESULTS: The mean primary tumor diameter was reported smaller in PET-CT and the effect size of PET-CT was -0.60. The kappa value was 0.06 for myometrial invasion. Pelvic lymph node metastasis was reported in 22.2% of patients in PET-CT. However, 3.7% of patients had pelvic lymph node metastasis. The kappa value for pelvic lymph node metastasis was 0.23, and sensitivity, specificity, and positive and negative predictive values were 100%, 80.7%, 16.6%, and 100%, respectively. Paraaortic lymph node metastasis in PET-CT was suspected in 10%. However, paraaortic lymph node metastasis was found in 6.7% in histopathologic analyses. The kappa value was 0.15. The sensitivity, specificity, and positive and negative predictive values of PET-CT for detecting paraaortic lymph node metastases were 100%, 93.7%, 66.6%, and 100%, respectively. Myometrial invasion and tumor diameter were the only important prognostic factors affecting SUV(max.) CONCLUSION: According to our results, PET-CT has a limited role and diagnostic efficacy in endometrial cancer. The indications of FDG/PET-CT in endometrium cancer should be studied further and revised. Galenos Publishing 2017-12 2017-12-30 /pmc/articles/PMC5780562/ /pubmed/29379661 http://dx.doi.org/10.4274/tjod.24572 Text en ©Copyright 2017 by Turkish Society of Obstetrics and Gynecology Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Erdemoğlu, Evrim Çerçi, Sevim Süreyya Erdemoğlu, Ebru Yalçın, Yakup Tatar, Burak Role of positron emission tomography-computed tomography in endometrial cancer |
title | Role of positron emission tomography-computed tomography in endometrial cancer |
title_full | Role of positron emission tomography-computed tomography in endometrial cancer |
title_fullStr | Role of positron emission tomography-computed tomography in endometrial cancer |
title_full_unstemmed | Role of positron emission tomography-computed tomography in endometrial cancer |
title_short | Role of positron emission tomography-computed tomography in endometrial cancer |
title_sort | role of positron emission tomography-computed tomography in endometrial cancer |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780562/ https://www.ncbi.nlm.nih.gov/pubmed/29379661 http://dx.doi.org/10.4274/tjod.24572 |
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