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Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia

Please cite this paper as: Ahn et al. (2011) Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia. Influenza and Other Respiratory Viruses 5(6), 398–403. Background  Mixed bacterial infection is an important contributor to morbid...

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Autores principales: Ahn, Shin, Kim, Won Young, Kim, Sung‐Han, Hong, SangBum, Lim, Chae‐Man, Koh, YounSuck, Lim, Kyung Soo, Kim, Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780656/
https://www.ncbi.nlm.nih.gov/pubmed/21668682
http://dx.doi.org/10.1111/j.1750-2659.2011.00244.x
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author Ahn, Shin
Kim, Won Young
Kim, Sung‐Han
Hong, SangBum
Lim, Chae‐Man
Koh, YounSuck
Lim, Kyung Soo
Kim, Won
author_facet Ahn, Shin
Kim, Won Young
Kim, Sung‐Han
Hong, SangBum
Lim, Chae‐Man
Koh, YounSuck
Lim, Kyung Soo
Kim, Won
author_sort Ahn, Shin
collection PubMed
description Please cite this paper as: Ahn et al. (2011) Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia. Influenza and Other Respiratory Viruses 5(6), 398–403. Background  Mixed bacterial infection is an important contributor to morbidity and mortality during influenza pandemics. We evaluated procalcitonin (PCT) and C‐reactive protein (CRP) in differentiating pneumonia caused by mixed bacterial and 2009 H1N1 influenza infection from 2009 H1N1 influenza infection alone. Methods  Data were collected retrospectively over a 7‐month period during the 2009 H1N1 influenza pandemic. Patients visiting emergency department and diagnosed as community‐acquired pneumonia caused by 2009 H1N1 infection were included (n = 60). Results  Mixed bacterial and viral infection pneumonia (n = 16) had significantly higher PCT and CRP levels than pneumonia caused by 2009 H1N1 influenza alone (n = 44, P = 0·019, 0·022 respectively). The sensitivity and specificity for detection of mixed bacterial infection pneumonia was 56% and 84% for PCT > 1·5 ng/ml, and 69% and 63% for CRP > 10 mg/dl. Using PCT and CRP in combination, the sensitivity and specificity were 50% and 93%, respectively. Conclusion  Procalcitonin and CRP alone and their combination had a moderate ability to detect pneumonia of mixed bacterial infection during the 2009 H1N1 pandemic. Considering high specificity, combination of low CRP and PCT result may suggest that pneumonia is unlikely to be caused by mixed bacterial infection.
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spelling pubmed-57806562018-02-06 Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia Ahn, Shin Kim, Won Young Kim, Sung‐Han Hong, SangBum Lim, Chae‐Man Koh, YounSuck Lim, Kyung Soo Kim, Won Influenza Other Respir Viruses Original Articles Please cite this paper as: Ahn et al. (2011) Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia. Influenza and Other Respiratory Viruses 5(6), 398–403. Background  Mixed bacterial infection is an important contributor to morbidity and mortality during influenza pandemics. We evaluated procalcitonin (PCT) and C‐reactive protein (CRP) in differentiating pneumonia caused by mixed bacterial and 2009 H1N1 influenza infection from 2009 H1N1 influenza infection alone. Methods  Data were collected retrospectively over a 7‐month period during the 2009 H1N1 influenza pandemic. Patients visiting emergency department and diagnosed as community‐acquired pneumonia caused by 2009 H1N1 infection were included (n = 60). Results  Mixed bacterial and viral infection pneumonia (n = 16) had significantly higher PCT and CRP levels than pneumonia caused by 2009 H1N1 influenza alone (n = 44, P = 0·019, 0·022 respectively). The sensitivity and specificity for detection of mixed bacterial infection pneumonia was 56% and 84% for PCT > 1·5 ng/ml, and 69% and 63% for CRP > 10 mg/dl. Using PCT and CRP in combination, the sensitivity and specificity were 50% and 93%, respectively. Conclusion  Procalcitonin and CRP alone and their combination had a moderate ability to detect pneumonia of mixed bacterial infection during the 2009 H1N1 pandemic. Considering high specificity, combination of low CRP and PCT result may suggest that pneumonia is unlikely to be caused by mixed bacterial infection. Blackwell Publishing Ltd 2011-03-30 2011-11 /pmc/articles/PMC5780656/ /pubmed/21668682 http://dx.doi.org/10.1111/j.1750-2659.2011.00244.x Text en © 2011 Blackwell Publishing Ltd
spellingShingle Original Articles
Ahn, Shin
Kim, Won Young
Kim, Sung‐Han
Hong, SangBum
Lim, Chae‐Man
Koh, YounSuck
Lim, Kyung Soo
Kim, Won
Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title_full Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title_fullStr Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title_full_unstemmed Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title_short Role of procalcitonin and C‐reactive protein in differentiation of mixed bacterial infection from 2009 H1N1 viral pneumonia
title_sort role of procalcitonin and c‐reactive protein in differentiation of mixed bacterial infection from 2009 h1n1 viral pneumonia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780656/
https://www.ncbi.nlm.nih.gov/pubmed/21668682
http://dx.doi.org/10.1111/j.1750-2659.2011.00244.x
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