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Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background Patients with end‐stage renal disease have a reduced response...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781215/ https://www.ncbi.nlm.nih.gov/pubmed/23078139 http://dx.doi.org/10.1111/irv.12024 |
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author | Quintana, Luis F. Serra, Nuria De Molina‐Llauradó, Patricia Blasco, Miquel Martinez, Mikel Campos, Begoña Bayas, Jose M. Pumarola, Tomás Campistol, Josep M. |
author_facet | Quintana, Luis F. Serra, Nuria De Molina‐Llauradó, Patricia Blasco, Miquel Martinez, Mikel Campos, Begoña Bayas, Jose M. Pumarola, Tomás Campistol, Josep M. |
author_sort | Quintana, Luis F. |
collection | PubMed |
description | Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix(®)) in four populations of renal patients after one and two doses of vaccine. Patients Methods 151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients. |
format | Online Article Text |
id | pubmed-5781215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57812152018-02-06 Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine Quintana, Luis F. Serra, Nuria De Molina‐Llauradó, Patricia Blasco, Miquel Martinez, Mikel Campos, Begoña Bayas, Jose M. Pumarola, Tomás Campistol, Josep M. Influenza Other Respir Viruses Part 2 Pandemic H1N1 Papers Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix(®)) in four populations of renal patients after one and two doses of vaccine. Patients Methods 151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients. Blackwell Publishing Ltd 2012-10-19 2013-09 /pmc/articles/PMC5781215/ /pubmed/23078139 http://dx.doi.org/10.1111/irv.12024 Text en © 2012 John Wiley & Sons Ltd |
spellingShingle | Part 2 Pandemic H1N1 Papers Quintana, Luis F. Serra, Nuria De Molina‐Llauradó, Patricia Blasco, Miquel Martinez, Mikel Campos, Begoña Bayas, Jose M. Pumarola, Tomás Campistol, Josep M. Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title | Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title_full | Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title_fullStr | Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title_full_unstemmed | Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title_short | Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine |
title_sort | influence of renal replacement therapy on immune response after one and two doses of the a(h1n1) pdm09 vaccine |
topic | Part 2 Pandemic H1N1 Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781215/ https://www.ncbi.nlm.nih.gov/pubmed/23078139 http://dx.doi.org/10.1111/irv.12024 |
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