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Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine

Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background  Patients with end‐stage renal disease have a reduced response...

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Autores principales: Quintana, Luis F., Serra, Nuria, De Molina‐Llauradó, Patricia, Blasco, Miquel, Martinez, Mikel, Campos, Begoña, Bayas, Jose M., Pumarola, Tomás, Campistol, Josep M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781215/
https://www.ncbi.nlm.nih.gov/pubmed/23078139
http://dx.doi.org/10.1111/irv.12024
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author Quintana, Luis F.
Serra, Nuria
De Molina‐Llauradó, Patricia
Blasco, Miquel
Martinez, Mikel
Campos, Begoña
Bayas, Jose M.
Pumarola, Tomás
Campistol, Josep M.
author_facet Quintana, Luis F.
Serra, Nuria
De Molina‐Llauradó, Patricia
Blasco, Miquel
Martinez, Mikel
Campos, Begoña
Bayas, Jose M.
Pumarola, Tomás
Campistol, Josep M.
author_sort Quintana, Luis F.
collection PubMed
description Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background  Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives  We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix(®)) in four populations of renal patients after one and two doses of vaccine. Patients Methods  151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results  The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions  Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients.
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spelling pubmed-57812152018-02-06 Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine Quintana, Luis F. Serra, Nuria De Molina‐Llauradó, Patricia Blasco, Miquel Martinez, Mikel Campos, Begoña Bayas, Jose M. Pumarola, Tomás Campistol, Josep M. Influenza Other Respir Viruses Part 2 Pandemic H1N1 Papers Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background  Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives  We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix(®)) in four populations of renal patients after one and two doses of vaccine. Patients Methods  151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results  The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions  Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients. Blackwell Publishing Ltd 2012-10-19 2013-09 /pmc/articles/PMC5781215/ /pubmed/23078139 http://dx.doi.org/10.1111/irv.12024 Text en © 2012 John Wiley & Sons Ltd
spellingShingle Part 2 Pandemic H1N1 Papers
Quintana, Luis F.
Serra, Nuria
De Molina‐Llauradó, Patricia
Blasco, Miquel
Martinez, Mikel
Campos, Begoña
Bayas, Jose M.
Pumarola, Tomás
Campistol, Josep M.
Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title_full Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title_fullStr Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title_full_unstemmed Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title_short Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine
title_sort influence of renal replacement therapy on immune response after one and two doses of the a(h1n1) pdm09 vaccine
topic Part 2 Pandemic H1N1 Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781215/
https://www.ncbi.nlm.nih.gov/pubmed/23078139
http://dx.doi.org/10.1111/irv.12024
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