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Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782474/ https://www.ncbi.nlm.nih.gov/pubmed/29497545 http://dx.doi.org/10.1093/omcr/omw046 |
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author | Alekseyev, Kirill Iannicello, Armando Amore, Giuseppe Rosenkranz, Travis Ross, Marc K. |
author_facet | Alekseyev, Kirill Iannicello, Armando Amore, Giuseppe Rosenkranz, Travis Ross, Marc K. |
author_sort | Alekseyev, Kirill |
collection | PubMed |
description | Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10–L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12–L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed. |
format | Online Article Text |
id | pubmed-5782474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57824742018-03-01 Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy Alekseyev, Kirill Iannicello, Armando Amore, Giuseppe Rosenkranz, Travis Ross, Marc K. Oxf Med Case Reports Case Report Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10–L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12–L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed. Oxford University Press 2016-08-29 /pmc/articles/PMC5782474/ /pubmed/29497545 http://dx.doi.org/10.1093/omcr/omw046 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Case Report Alekseyev, Kirill Iannicello, Armando Amore, Giuseppe Rosenkranz, Travis Ross, Marc K. Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy |
title | Thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
title_full | Thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
title_fullStr | Thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
title_full_unstemmed | Thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
title_short | Thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
title_sort | thymic carcinoma with metastasis in a 29-year-old male causing
radiculopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782474/ https://www.ncbi.nlm.nih.gov/pubmed/29497545 http://dx.doi.org/10.1093/omcr/omw046 |
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