Cargando…

Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy

Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report...

Descripción completa

Detalles Bibliográficos
Autores principales: Alekseyev, Kirill, Iannicello, Armando, Amore, Giuseppe, Rosenkranz, Travis, Ross, Marc K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782474/
https://www.ncbi.nlm.nih.gov/pubmed/29497545
http://dx.doi.org/10.1093/omcr/omw046
_version_ 1783295201871134720
author Alekseyev, Kirill
Iannicello, Armando
Amore, Giuseppe
Rosenkranz, Travis
Ross, Marc K.
author_facet Alekseyev, Kirill
Iannicello, Armando
Amore, Giuseppe
Rosenkranz, Travis
Ross, Marc K.
author_sort Alekseyev, Kirill
collection PubMed
description Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10–L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12–L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed.
format Online
Article
Text
id pubmed-5782474
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-57824742018-03-01 Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy Alekseyev, Kirill Iannicello, Armando Amore, Giuseppe Rosenkranz, Travis Ross, Marc K. Oxf Med Case Reports Case Report Thymic carcinoma is a rare, aggressive neoplasm with low 5-year survival rates ranging from 28 to 67%. Initial presentation with spinal or bone metastasis in primary thymic carcinoma is extremely rare. Thymic carcinoma, compared with thymoma, has higher recurrence rates and worse survival. We report one patient, a 29-year-old African-American male, with thymic carcinoma with metastasis to the epidural space (with cord compression), multiple bony structures (T10–L1) and left supraclavicular lymph node. Immunohistochemical staining was CD5 and c-Kit positive, consistent with thymic carcinoma. Patient underwent T12–L1 laminectomy with tumor resection to relieve cord compression and leg numbness/weakness. Patient was deemed a good candidate for rehabilitation. Soon after starting a rehabilitation program, he quickly demonstrated gains in gait distance with little to no assistance. Follow-up appointments with oncology were scheduled, and further planning of radiation and chemotherapy treatments were discussed. Oxford University Press 2016-08-29 /pmc/articles/PMC5782474/ /pubmed/29497545 http://dx.doi.org/10.1093/omcr/omw046 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Alekseyev, Kirill
Iannicello, Armando
Amore, Giuseppe
Rosenkranz, Travis
Ross, Marc K.
Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title_full Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title_fullStr Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title_full_unstemmed Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title_short Thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
title_sort thymic carcinoma with metastasis in a 29-year-old male causing radiculopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782474/
https://www.ncbi.nlm.nih.gov/pubmed/29497545
http://dx.doi.org/10.1093/omcr/omw046
work_keys_str_mv AT alekseyevkirill thymiccarcinomawithmetastasisina29yearoldmalecausingradiculopathy
AT iannicelloarmando thymiccarcinomawithmetastasisina29yearoldmalecausingradiculopathy
AT amoregiuseppe thymiccarcinomawithmetastasisina29yearoldmalecausingradiculopathy
AT rosenkranztravis thymiccarcinomawithmetastasisina29yearoldmalecausingradiculopathy
AT rossmarck thymiccarcinomawithmetastasisina29yearoldmalecausingradiculopathy