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Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis
INTRODUCTION: Breast cancer is the most common cancer in women worldwide. The association between body mass index (BMI) and breast cancer risk has been paid more attention in the past few years, but the findings are still controversial. To obtain a more reliable conclusion, we performed a dose–respo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783020/ https://www.ncbi.nlm.nih.gov/pubmed/29403312 http://dx.doi.org/10.2147/CMAR.S144619 |
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author | Liu, Kang Zhang, Weining Dai, Zhiming Wang, Meng Tian, Tian Liu, Xinghan Kang, Huafeng Guan, Haitao Zhang, Shuqun Dai, Zhijun |
author_facet | Liu, Kang Zhang, Weining Dai, Zhiming Wang, Meng Tian, Tian Liu, Xinghan Kang, Huafeng Guan, Haitao Zhang, Shuqun Dai, Zhijun |
author_sort | Liu, Kang |
collection | PubMed |
description | INTRODUCTION: Breast cancer is the most common cancer in women worldwide. The association between body mass index (BMI) and breast cancer risk has been paid more attention in the past few years, but the findings are still controversial. To obtain a more reliable conclusion, we performed a dose–response meta-analysis on 12 prospective cohort studies comprising 22,728,674 participants. METHODS: Linear and nonlinear trend analyses were conducted to explore the dose–response relationship between BMI and breast cancer risk. The summary relative risk (SRR) and 95% confidence intervals (CIs) were used to evaluate the cancer risk. RESULTS: The overall results showed a weak positive association between a 5-unit increase in BMI and breast cancer risk, indicating that a 5 kg/m(2) increase in BMI corresponded to a 2% increase in breast cancer risk (SRR: 1.02, 95% CI: 1.01–1.04, p<0.001). Notably, further subgroup meta-analysis found that higher BMI could be a protective factor of breast cancer risk for premenopausal women (SRR: 0.98, 95% CI: 0.96–0.99, p<0.001). In addition, the dose–response result demonstrated that there was a linear association between BMI and breast cancer risk (P(nonlinearity)=0.754). CONCLUSION: In summary, this dose–response meta-analysis of prospective cohort studies showed that every 5 kg/m(2) increase in BMI corresponded to a 2% increase in breast cancer risk in women. However, higher BMI could be a protective factor in breast cancer risk for premenopausal women. Further studies are necessary to verify these findings and elucidate the pathogenic mechanisms. |
format | Online Article Text |
id | pubmed-5783020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57830202018-02-05 Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis Liu, Kang Zhang, Weining Dai, Zhiming Wang, Meng Tian, Tian Liu, Xinghan Kang, Huafeng Guan, Haitao Zhang, Shuqun Dai, Zhijun Cancer Manag Res Original Research INTRODUCTION: Breast cancer is the most common cancer in women worldwide. The association between body mass index (BMI) and breast cancer risk has been paid more attention in the past few years, but the findings are still controversial. To obtain a more reliable conclusion, we performed a dose–response meta-analysis on 12 prospective cohort studies comprising 22,728,674 participants. METHODS: Linear and nonlinear trend analyses were conducted to explore the dose–response relationship between BMI and breast cancer risk. The summary relative risk (SRR) and 95% confidence intervals (CIs) were used to evaluate the cancer risk. RESULTS: The overall results showed a weak positive association between a 5-unit increase in BMI and breast cancer risk, indicating that a 5 kg/m(2) increase in BMI corresponded to a 2% increase in breast cancer risk (SRR: 1.02, 95% CI: 1.01–1.04, p<0.001). Notably, further subgroup meta-analysis found that higher BMI could be a protective factor of breast cancer risk for premenopausal women (SRR: 0.98, 95% CI: 0.96–0.99, p<0.001). In addition, the dose–response result demonstrated that there was a linear association between BMI and breast cancer risk (P(nonlinearity)=0.754). CONCLUSION: In summary, this dose–response meta-analysis of prospective cohort studies showed that every 5 kg/m(2) increase in BMI corresponded to a 2% increase in breast cancer risk in women. However, higher BMI could be a protective factor in breast cancer risk for premenopausal women. Further studies are necessary to verify these findings and elucidate the pathogenic mechanisms. Dove Medical Press 2018-01-18 /pmc/articles/PMC5783020/ /pubmed/29403312 http://dx.doi.org/10.2147/CMAR.S144619 Text en © 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Liu, Kang Zhang, Weining Dai, Zhiming Wang, Meng Tian, Tian Liu, Xinghan Kang, Huafeng Guan, Haitao Zhang, Shuqun Dai, Zhijun Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title | Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title_full | Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title_fullStr | Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title_full_unstemmed | Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title_short | Association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
title_sort | association between body mass index and breast cancer risk: evidence based on a dose–response meta-analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783020/ https://www.ncbi.nlm.nih.gov/pubmed/29403312 http://dx.doi.org/10.2147/CMAR.S144619 |
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