Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

The imidazole-based H3R antagonist 2-18 with high in vitro H3R antagonist affinity, excellent in vitro selectivity profile, and high in vivo H3R antagonist potency was tested for its anticonvulsant effect in maximal electroshock (MES)-induced convulsions in mice having valproic acid (VPA) as a refer...

Descripción completa

Detalles Bibliográficos
Autores principales: Bastaki, Salim M, Abdulrazzaq, Yousef M, Shafiullah, Mohamed, Więcek, Małgorzata, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783147/
https://www.ncbi.nlm.nih.gov/pubmed/29403264
http://dx.doi.org/10.2147/DDDT.S144730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783147/
https://www.ncbi.nlm.nih.gov/pubmed/29403264
http://dx.doi.org/10.2147/DDDT.S144730

Ejemplares similares