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Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

The imidazole-based H3R antagonist 2-18 with high in vitro H3R antagonist affinity, excellent in vitro selectivity profile, and high in vivo H3R antagonist potency was tested for its anticonvulsant effect in maximal electroshock (MES)-induced convulsions in mice having valproic acid (VPA) as a refer...

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Detalles Bibliográficos
Autores principales:	Bastaki, Salim M, Abdulrazzaq, Yousef M, Shafiullah, Mohamed, Więcek, Małgorzata, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783147/ https://www.ncbi.nlm.nih.gov/pubmed/29403264 http://dx.doi.org/10.2147/DDDT.S144730

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