RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, the causal mutation for 17 neurological diseases. Increased expansion frequ...

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Detalles Bibliográficos
Autores principales: Frizzell, Aisling, Nguyen, Jennifer H.G., Petalcorin, Mark I.R., Turner, Katherine D., Boulton, Simon J., Freudenreich, Catherine H., Lahue, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783307/
https://www.ncbi.nlm.nih.gov/pubmed/24561255
http://dx.doi.org/10.1016/j.celrep.2014.01.034

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