5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice

In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have demonstrated the potential of ALA as a treatment f...

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Detalles Bibliográficos
Autores principales: Saitoh, Shinichi, Okano, Satoshi, Nohara, Hidekazu, Nakano, Hiroshi, Shirasawa, Nobuyuki, Naito, Akira, Yamamoto, Masayuki, Kelly, Vincent P., Takahashi, Kiwamu, Tanaka, Tohru, Nakajima, Motowo, Nakajima, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783358/
https://www.ncbi.nlm.nih.gov/pubmed/29364890
http://dx.doi.org/10.1371/journal.pone.0189593

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