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Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism
The current study observed the percentage of peripheral blood (PB) CD4(+)CD25(+) regulatory T cells (Tregs) and the influence of CD4(+)CD25(+) Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783454/ https://www.ncbi.nlm.nih.gov/pubmed/29207121 http://dx.doi.org/10.3892/mmr.2017.8154 |
Sumario: | The current study observed the percentage of peripheral blood (PB) CD4(+)CD25(+) regulatory T cells (Tregs) and the influence of CD4(+)CD25(+) Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4(+)CD25(+) Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4(+)CD25(+) Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4(+)CD25(+) Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (P<0.05). In addition, it was demonstrated that thyroid function of patients with hyperthyroidism was significantly improved (P<0.05) subsequent to receiving medication. Compared with the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4(+)CD25(+) Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (P<0.05). PB CD4(+)CD25(+) Tregs function was decreased in patients with hyperthyroidism, and its non-proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism. |
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