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Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism
The current study observed the percentage of peripheral blood (PB) CD4(+)CD25(+) regulatory T cells (Tregs) and the influence of CD4(+)CD25(+) Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783454/ https://www.ncbi.nlm.nih.gov/pubmed/29207121 http://dx.doi.org/10.3892/mmr.2017.8154 |
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author | Jiang, Ting-Jun Cao, Xue-Liang Luan, Sha Cui, Wan-Hui Qiu, Si-Huang Wang, Yi-Chao Zhao, Chang-Jiu Fu, Peng |
author_facet | Jiang, Ting-Jun Cao, Xue-Liang Luan, Sha Cui, Wan-Hui Qiu, Si-Huang Wang, Yi-Chao Zhao, Chang-Jiu Fu, Peng |
author_sort | Jiang, Ting-Jun |
collection | PubMed |
description | The current study observed the percentage of peripheral blood (PB) CD4(+)CD25(+) regulatory T cells (Tregs) and the influence of CD4(+)CD25(+) Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4(+)CD25(+) Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4(+)CD25(+) Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4(+)CD25(+) Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (P<0.05). In addition, it was demonstrated that thyroid function of patients with hyperthyroidism was significantly improved (P<0.05) subsequent to receiving medication. Compared with the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4(+)CD25(+) Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (P<0.05). PB CD4(+)CD25(+) Tregs function was decreased in patients with hyperthyroidism, and its non-proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism. |
format | Online Article Text |
id | pubmed-5783454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-57834542018-02-05 Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism Jiang, Ting-Jun Cao, Xue-Liang Luan, Sha Cui, Wan-Hui Qiu, Si-Huang Wang, Yi-Chao Zhao, Chang-Jiu Fu, Peng Mol Med Rep Articles The current study observed the percentage of peripheral blood (PB) CD4(+)CD25(+) regulatory T cells (Tregs) and the influence of CD4(+)CD25(+) Tregs on the proliferation of naïve CD4 T cells in patients with hyperthyroidism. Furthermore, preliminary discussions are presented on the action mechanism of CD4(+)CD25(+) Tregs on hyperthyroidism attacks. The present study identified that compared with the percentage of PB CD4(+)CD25(+) Tregs in healthy control subjects, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism (P>0.05). For patients with hyperthyroidism, CD4(+)CD25(+) Tregs exhibited significantly reduced inhibition of the proliferation of naïve CD4 T cells and decreased secretion capacity on the cytokines of CD4 T cells, compared with those of healthy control subjects (P<0.05). In addition, it was demonstrated that thyroid function of patients with hyperthyroidism was significantly improved (P<0.05) subsequent to receiving medication. Compared with the percentage of PB CD4(+)CD25(+) Tregs in patients with hyperthyroidism before treatment, no significant changes were observed in the percentage of PB CD4(+)CD25(+) Tregs in hyperthyroidism patients following treatment (P>0.05). In the patients with hyperthyroidism, following treatment, CD4(+)CD25(+) Tregs exhibited significantly increased inhibition of the proliferation of naïve CD4 T cells and increased secretion capacity of CD4 T cell cytokines, compared with those of the patients with hyperthyroidism prior to treatment (P<0.05). PB CD4(+)CD25(+) Tregs function was decreased in patients with hyperthyroidism, and its non-proportional decrease may be closely associated with the occurrence and progression of hyperthyroidism. D.A. Spandidos 2018-02 2017-11-27 /pmc/articles/PMC5783454/ /pubmed/29207121 http://dx.doi.org/10.3892/mmr.2017.8154 Text en Copyright: © Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Jiang, Ting-Jun Cao, Xue-Liang Luan, Sha Cui, Wan-Hui Qiu, Si-Huang Wang, Yi-Chao Zhao, Chang-Jiu Fu, Peng Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title | Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title_full | Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title_fullStr | Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title_full_unstemmed | Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title_short | Percentage and function of CD4(+)CD25(+) regulatory T cells in patients with hyperthyroidism |
title_sort | percentage and function of cd4(+)cd25(+) regulatory t cells in patients with hyperthyroidism |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783454/ https://www.ncbi.nlm.nih.gov/pubmed/29207121 http://dx.doi.org/10.3892/mmr.2017.8154 |
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