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Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells

The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP-TFII expression and the occurren...

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Autores principales: Ding, Weiji, Zhang, Yunda, Cai, Huali, Liu, Gang, Ye, Yongzhi, Xu, Guoxing, Wang, Haibin, Xiong, Disheng, Zhang, Chuankai, Huang, Zhengjie, Luo, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783485/
https://www.ncbi.nlm.nih.gov/pubmed/29207189
http://dx.doi.org/10.3892/mmr.2017.8164
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author Ding, Weiji
Zhang, Yunda
Cai, Huali
Liu, Gang
Ye, Yongzhi
Xu, Guoxing
Wang, Haibin
Xiong, Disheng
Zhang, Chuankai
Huang, Zhengjie
Luo, Qi
author_facet Ding, Weiji
Zhang, Yunda
Cai, Huali
Liu, Gang
Ye, Yongzhi
Xu, Guoxing
Wang, Haibin
Xiong, Disheng
Zhang, Chuankai
Huang, Zhengjie
Luo, Qi
author_sort Ding, Weiji
collection PubMed
description The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP-TFII expression and the occurrence, recurrence, invasion and metastasis of gastric cancer are limited in number. In the present study, it was revealed that the expression of COUP-TFII is significantly reduced in gastric carcinoma tissues compared with normal gastric mucosa cells (GES-1). In addition, the expression of COUP-TFII was also reduced in gastric cancer cell lines compared with GES-1 cells. Furthermore, it was revealed that ectopic expression of COUP-TFII was able to suppress the proliferation, migration and invasion of gastric cells, as well as inhibit hepatic metastasis, in vivo. In addition, it was demonstrated that COUP-TFII knockdown was able to promote the proliferation, migration and invasion of GES-1 cells in vitro. Furthermore, database analysis suggested that COUP-TFII expression in patients with gastric cancer is correlated with clinical stage classification and increased expression levels of COUP-TFII improved overall survival rates in patients with gastric cancer. The results of the present study suggest that COUP-TFII functions as a significant regulatory suppressor of gastric cancer growth and metastasis, and suggests that COUP-TFII may serve as a novel diagnostic and prognostic biomarker for gastric cancer metastasis.
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spelling pubmed-57834852018-02-05 Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells Ding, Weiji Zhang, Yunda Cai, Huali Liu, Gang Ye, Yongzhi Xu, Guoxing Wang, Haibin Xiong, Disheng Zhang, Chuankai Huang, Zhengjie Luo, Qi Mol Med Rep Articles The abnormal expression of the chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) is associated with numerous forms of cancer, including gastric, prostate, colon and lung cancer. However, previous studies investigating the association between COUP-TFII expression and the occurrence, recurrence, invasion and metastasis of gastric cancer are limited in number. In the present study, it was revealed that the expression of COUP-TFII is significantly reduced in gastric carcinoma tissues compared with normal gastric mucosa cells (GES-1). In addition, the expression of COUP-TFII was also reduced in gastric cancer cell lines compared with GES-1 cells. Furthermore, it was revealed that ectopic expression of COUP-TFII was able to suppress the proliferation, migration and invasion of gastric cells, as well as inhibit hepatic metastasis, in vivo. In addition, it was demonstrated that COUP-TFII knockdown was able to promote the proliferation, migration and invasion of GES-1 cells in vitro. Furthermore, database analysis suggested that COUP-TFII expression in patients with gastric cancer is correlated with clinical stage classification and increased expression levels of COUP-TFII improved overall survival rates in patients with gastric cancer. The results of the present study suggest that COUP-TFII functions as a significant regulatory suppressor of gastric cancer growth and metastasis, and suggests that COUP-TFII may serve as a novel diagnostic and prognostic biomarker for gastric cancer metastasis. D.A. Spandidos 2018-02 2017-11-27 /pmc/articles/PMC5783485/ /pubmed/29207189 http://dx.doi.org/10.3892/mmr.2017.8164 Text en Copyright: © Ding et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Ding, Weiji
Zhang, Yunda
Cai, Huali
Liu, Gang
Ye, Yongzhi
Xu, Guoxing
Wang, Haibin
Xiong, Disheng
Zhang, Chuankai
Huang, Zhengjie
Luo, Qi
Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title_full Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title_fullStr Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title_full_unstemmed Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title_short Overexpression of COUP-TFII suppresses proliferation and metastasis of human gastric cancer cells
title_sort overexpression of coup-tfii suppresses proliferation and metastasis of human gastric cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783485/
https://www.ncbi.nlm.nih.gov/pubmed/29207189
http://dx.doi.org/10.3892/mmr.2017.8164
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