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The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma
Accumulating evidence indicates that mitotic checkpoint serine/threonine kinase B (BUB1B) plays a critical role in multiple types of cancer. However, the biological function and molecular regulatory mechanism of BUB1B in glioblastoma (GBM) remain unclear. In the present study, we identified that BUB...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783581/ https://www.ncbi.nlm.nih.gov/pubmed/29039578 http://dx.doi.org/10.3892/or.2017.6032 |
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author | Ma, Qing Liu, Yanmei Shang, Liang Yu, Jiao Qu, Qiumin |
author_facet | Ma, Qing Liu, Yanmei Shang, Liang Yu, Jiao Qu, Qiumin |
author_sort | Ma, Qing |
collection | PubMed |
description | Accumulating evidence indicates that mitotic checkpoint serine/threonine kinase B (BUB1B) plays a critical role in multiple types of cancer. However, the biological function and molecular regulatory mechanism of BUB1B in glioblastoma (GBM) remain unclear. In the present study, we identified that BUB1B expression was enriched in GBM tumors and was functionally required for tumor proliferation both in vitro and in vivo. Clinically, BUB1B expression was associated with poor prognosis in GBM patients and BUB1B-dependent radioresistance in GBM was decreased by targeting BUB1B via shRNAs. Mechanistically, forkhead box protein M1 (FOXM1) transcriptionally regulated BUB1B expression by binding to and then activating the BUB1B promoter. Therapeutically, we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of GBM both in vitro and in vivo. Altogether, BUB1B promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B could be a potential therapeutic target for GBM. |
format | Online Article Text |
id | pubmed-5783581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-57835812018-02-12 The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma Ma, Qing Liu, Yanmei Shang, Liang Yu, Jiao Qu, Qiumin Oncol Rep Articles Accumulating evidence indicates that mitotic checkpoint serine/threonine kinase B (BUB1B) plays a critical role in multiple types of cancer. However, the biological function and molecular regulatory mechanism of BUB1B in glioblastoma (GBM) remain unclear. In the present study, we identified that BUB1B expression was enriched in GBM tumors and was functionally required for tumor proliferation both in vitro and in vivo. Clinically, BUB1B expression was associated with poor prognosis in GBM patients and BUB1B-dependent radioresistance in GBM was decreased by targeting BUB1B via shRNAs. Mechanistically, forkhead box protein M1 (FOXM1) transcriptionally regulated BUB1B expression by binding to and then activating the BUB1B promoter. Therapeutically, we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of GBM both in vitro and in vivo. Altogether, BUB1B promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B could be a potential therapeutic target for GBM. D.A. Spandidos 2017-12 2017-10-12 /pmc/articles/PMC5783581/ /pubmed/29039578 http://dx.doi.org/10.3892/or.2017.6032 Text en Copyright: © Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Ma, Qing Liu, Yanmei Shang, Liang Yu, Jiao Qu, Qiumin The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title | The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title_full | The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title_fullStr | The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title_full_unstemmed | The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title_short | The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
title_sort | foxm1/bub1b signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783581/ https://www.ncbi.nlm.nih.gov/pubmed/29039578 http://dx.doi.org/10.3892/or.2017.6032 |
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