Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is an incurable childhood brain tumor. The mechanistic target of rapamycin (MTOR), a key oncogene, functions as two distinct signaling complexes, MTORC1 and MTORC2. We set out to determine the preclinical efficacy and mechanism of action of MTOR inhibitors in...

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Detalles Bibliográficos
Autores principales: Flannery, Patrick C., Desisto, John A., Amani, Vladimir, Venkataraman, Sujatha, Lemma, Rakeb T., Prince, Eric W., Donson, Andrew, Moroze, Erin E., Hoffman, Lindsey, Levy, Jean M. Mulcahy, Foreman, Nicholas, Vibhakar, Rajeev, Green, Adam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783612/
https://www.ncbi.nlm.nih.gov/pubmed/29207163
http://dx.doi.org/10.3892/or.2017.6122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783612/
https://www.ncbi.nlm.nih.gov/pubmed/29207163
http://dx.doi.org/10.3892/or.2017.6122

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