Cargando…

Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is an incurable childhood brain tumor. The mechanistic target of rapamycin (MTOR), a key oncogene, functions as two distinct signaling complexes, MTORC1 and MTORC2. We set out to determine the preclinical efficacy and mechanism of action of MTOR inhibitors in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flannery, Patrick C., Desisto, John A., Amani, Vladimir, Venkataraman, Sujatha, Lemma, Rakeb T., Prince, Eric W., Donson, Andrew, Moroze, Erin E., Hoffman, Lindsey, Levy, Jean M. Mulcahy, Foreman, Nicholas, Vibhakar, Rajeev, Green, Adam L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783612/ https://www.ncbi.nlm.nih.gov/pubmed/29207163 http://dx.doi.org/10.3892/or.2017.6122

Ejemplares similares

Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma
por: Amani, Vladimir, et al.
Publicado: (2016)

Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine
por: Green, Adam L, et al.
Publicado: (2020)

DIPG-79. H3K27M INDUCES EPIGENETIC AND ONCOGENIC CHANGES THAT ARE PARTIALLY REVERSED BY SMALL MOLECULE AURORA KINASE B/C INHIBITION
por: Chatwin, Hannah, et al.
Publicado: (2020)

HGG-18. SINGLE CELL RNA-SEQ ANALYSIS OF PEDIATRIC HIGH-GRADE GLIOMA PATIENT SAMPLES IDENTIFIES COMMON GLIAL AND IMMUNE CELL TYPES THAT HELP TO EXPLAIN HETEROGENEITY AND TUMORIGENESIS
por: DeSisto, John, et al.
Publicado: (2023)

MODL-31. RADIATION-DERIVED TREATMENT-RESISTANT PDX AND CELL CULTURE MODELS RECAPITULATE THE CHARACTERISTICS OF MATCHED PRIMARY/RECURRENT PEDIATRIC HIGH-GRADE GLIOMA
por: Knox, Aaron J, et al.
Publicado: (2020)

Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor
por: Alimova, Irina, et al.
Publicado: (2017)

A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease
por: Knox, Aaron J., et al.
Publicado: (2023)

IMMU-23. Novel gene-edited CAR-T cell therapy against Diffuse Intrinsic Pontine Glioma
por: Balakrishnan, Ilango, et al.
Publicado: (2022)

MEDB-44. Transcriptomic resolution of subgroup-specific medulloblastoma architecture
por: Willard, Nicholas, et al.
Publicado: (2022)

XRT-02. SINGLE-CELL RNA SEQUENCING IDENTIFIES FUNCTIONAL MACROPHAGE SUBSETS THAT ARE ENRICHED IN RESPONSE TO DIFFERENTIAL PHAGOCYTOSIS INDUCTION AGAINST GLIOMA
por: Lakshmanachetty, Senthilnath, et al.
Publicado: (2023)

BPTF Regulates Growth of Adult and Pediatric High-Grade Glioma through the MYC Pathway
por: Green, Adam L., et al.
Publicado: (2019)

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
por: DeSisto, John, et al.
Publicado: (2021)

MPS1 kinase as a potential therapeutic target in medulloblastoma
por: Alimova, Irina, et al.
Publicado: (2016)

EPEN-31. SINGLE-CELL RNAseq OF CHILDHOOD EPENDYMOMA REVEALS DISTINCT NEOPLASTIC CELL SUBPOPULATIONS THAT IMPACT ETIOLOGY, MOLECULAR CLASSIFICATION AND OUTCOME
por: Donson, Andrew, et al.
Publicado: (2020)

HGG-25. PRMT5 PROMOTES TUMOR GROWTH BY MAINTAINING STEMNESS OF PEDIATRIC HIGH-GRADE GLIOMA CELLS
por: DeSisto, John, et al.
Publicado: (2021)

Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma
por: Prince, Eric W., et al.
Publicado: (2016)

HGG-57. WHOLE-GENOME SEQUENCING, METHYLATION ANALYSIS, AND SINGLE-CELL RNA-SEQ DEFINE UNIQUE CHARACTERISTICS OF PEDIATRIC TREATMENT-INDUCED HIGH-GRADE GLIOMA AND SUGGEST ONCOGENIC MECHANISMS
por: Lucas, John, et al.
Publicado: (2020)

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence
por: Venkataraman, Sujatha, et al.
Publicado: (2010)

HGG-20. PRMT5 promotes the formation and growth of pediatric high-grade glioma by maintaining tumor stem cell populations
por: DeSisto, John, et al.
Publicado: (2022)

MBRS-46. CHARTING NEOPLASTIC AND IMMUNE CELL HETEROGENEITY IN HUMAN AND GEM MODELS OF MEDULLOBLASTOMA USING scRNAseq
por: Donson, Andrew, et al.
Publicado: (2020)

MEDB-70. Metabolism mediated radiation resistance in MYC-driven Medulloblastoma
por: Veo, Bethany, et al.
Publicado: (2022)

A Regulatory Loop of FBXW7-MYC-PLK1 Controls Tumorigenesis of MYC-Driven Medulloblastoma
por: Wang, Dong, et al.
Publicado: (2021)

RONC-05. Peri-transplant Radiation Therapy for Young Children Treated with High-Dose Chemotherapy for Primary Brain Tumors
por: Milgrom, Sarah, et al.
Publicado: (2022)

ATRT-24. CDK7 Inhibition in AT/RT
por: Morin, Andrew, et al.
Publicado: (2022)

Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
por: Harris, Peter S, et al.
Publicado: (2012)

Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors
por: Alimova, Irina, et al.
Publicado: (2022)

LGG-22. CHARACTERIZATION OF THE TUMOR MICROENVIRONMENT IN PEDIATRIC LOW-GRADE GLIOMA
por: Zahedi, Shadi, et al.
Publicado: (2023)

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
por: Harris, Peter S, et al.
Publicado: (2014)

DIPG-42. TOWARD MULTIMODALITY THERAPY FOR DIPG/DMG: DEVELOPMENT AND INVESTIGATION OF CRANIOSPINAL IRRADIATION AND CONVECTION-ENHANCED DELIVERY PDX MODELS
por: Knox, Aaron J, et al.
Publicado: (2020)

Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma
por: Bhatia, Shilpa, et al.
Publicado: (2017)

Radiation Therapy for Young Children Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant for Primary Brain Tumors
por: Milgrom, Sarah A., et al.
Publicado: (2022)

QOL-36. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION
por: Dorris, Kathleen, et al.
Publicado: (2020)

EPEN-26. NON-CANONICAL NF-κB SIGNALING DRIVES MESENCHYMAL EPENDYMAL CELL SUBPOPULATION IN PFA EPENDYMOMA
por: Griesinger, Andrea, et al.
Publicado: (2020)

MEDB-80. CDK8 promotes stemness of MYC-driven medulloblastoma
por: Wang, Dong, et al.
Publicado: (2022)

MEDB-81. Combined inhibition of CDK11 and EZH2 results in regression of MYC-amplified medulloblastoma
por: Wang, Dong, et al.
Publicado: (2022)

Immunogenic Cell Death Enhances Immunotherapy of Diffuse Intrinsic Pontine Glioma: From Preclinical to Clinical Studies
por: Liu, Guohao, et al.
Publicado: (2022)

DIPG-06. PRECLINICAL EVALUATION OF A NOVEL ACVR1 INHIBITOR IN DIFFUSE INTRINSIC PONTINE GLIOMAS
por: Kumar, Shiva Senthil, et al.
Publicado: (2023)

Targeting IL-6 Is a Potential Treatment for Primary Cystic Craniopharyngioma
por: Grob, Sydney, et al.
Publicado: (2019)

Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma
por: Tsoli, Maria, et al.
Publicado: (2018)

EMBR-27. NEOPLASTIC AND IMMUNE SINGLE CELL TRANSCRIPTOMICS DEFINE SUBGROUP-SPECIFIC INTRA-TUMORAL HETEROGENEITY OF CHILDHOOD MEDULLOBLASTOMA
por: Donson, Andrew, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_159iggc4dib2goa90931ge4rk5