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Screening and antitumor effect of an anti-CTLA-4 nanobody

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a critical negative regulator of immune responses. CTLA-4 is rapidly upregulated following T-cell activation, and then binds to B7 molecules with a higher affinity than CD28. CTLA-4 may abolish the initiation of the responses of T cells by raising the thr...

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Detalles Bibliográficos
Autores principales:	Wan, Ruirong, Liu, Aiqun, Hou, Xiaoqiong, Lai, Zongqiang, Li, Jieping, Yang, Nuo, Tan, Juntao, Mo, Fengzhen, Hu, Zixi, Yang, Xiaomei, Zhao, Yongxiang, Lu, Xiaoling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783618/ https://www.ncbi.nlm.nih.gov/pubmed/29207143 http://dx.doi.org/10.3892/or.2017.6131

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