Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma

PURPOSE: Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test drug efficacy and toxicity in vivo for IAC drug discovery. The purpose of this study was to develop a small-animal model of IAC and to...

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Detalles Bibliográficos
Autores principales: Daniels, Anthony B., Froehler, Michael T., Pierce, Janene M., Nunnally, Amy H., Calcutt, M. Wade, Bridges, Thomas M., LaNeve, David C., Williams, Phillip E., Boyd, Kelli L., Reyzer, Michelle L., Lindsley, Craig W., Friedman, Debra L., Richmond, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Anatomy and Pathology/Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783625/
https://www.ncbi.nlm.nih.gov/pubmed/29368001
http://dx.doi.org/10.1167/iovs.17-22302

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