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Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California

BACKGROUND: Prior studies suggest neurodevelopmental impacts of polybrominated diphenyl ethers (PBDEs), but few have examined diagnosed developmental disorders. OBJECTIVES: Our aim was to determine whether prenatal exposure to brominated flame retardants (BFRs) is associated with autism spectrum dis...

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Autores principales: Lyall, Kristen, Croen, Lisa A., Weiss, Lauren A., Kharrazi, Martin, Traglia, Michela, Delorenze, Gerald N., Windham, Gayle C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783661/
https://www.ncbi.nlm.nih.gov/pubmed/28895873
http://dx.doi.org/10.1289/EHP1079
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author Lyall, Kristen
Croen, Lisa A.
Weiss, Lauren A.
Kharrazi, Martin
Traglia, Michela
Delorenze, Gerald N.
Windham, Gayle C.
author_facet Lyall, Kristen
Croen, Lisa A.
Weiss, Lauren A.
Kharrazi, Martin
Traglia, Michela
Delorenze, Gerald N.
Windham, Gayle C.
author_sort Lyall, Kristen
collection PubMed
description BACKGROUND: Prior studies suggest neurodevelopmental impacts of polybrominated diphenyl ethers (PBDEs), but few have examined diagnosed developmental disorders. OBJECTIVES: Our aim was to determine whether prenatal exposure to brominated flame retardants (BFRs) is associated with autism spectrum disorder (ASD) or intellectual disability without autism (ID). METHODS: We conducted a population-based case–control study including children with ASD ([Formula: see text]) and ID ([Formula: see text]) identified from the California Department of Developmental Services and general population (GP) controls ([Formula: see text]) from state birth certificates. ASD cases were matched to controls by sex, birth month, and birth year. Concentrations of 10 BFRs were measured in maternal second trimester serum samples stored from routine screening. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses. RESULTS: Geometric mean concentrations of five of the six congeners with [Formula: see text] of samples above the limit of detection were lower in mothers of children with ASD or ID than in controls. In adjusted analyses, inverse associations with several congeners were found for ASD relative to GP (e.g., quartile 4 vs. 1, BDE-153: [Formula: see text] , 95% CI: 0.38, 0.84). When stratified by child sex (including 99 females with ASD, 77 with ID, and 73 with GP), estimates were consistent with overall analyses in boys, but in the opposite direction among girls, particularly for BDE-28 and -47 ([Formula: see text] , 95% CI: 0.86, 7.79 and [Formula: see text] , 95% CI: 0.97, 7.19, respectively). Similar patterns overall and by sex were observed for ID. CONCLUSIONS: Contrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079
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spelling pubmed-57836612018-03-02 Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California Lyall, Kristen Croen, Lisa A. Weiss, Lauren A. Kharrazi, Martin Traglia, Michela Delorenze, Gerald N. Windham, Gayle C. Environ Health Perspect Research BACKGROUND: Prior studies suggest neurodevelopmental impacts of polybrominated diphenyl ethers (PBDEs), but few have examined diagnosed developmental disorders. OBJECTIVES: Our aim was to determine whether prenatal exposure to brominated flame retardants (BFRs) is associated with autism spectrum disorder (ASD) or intellectual disability without autism (ID). METHODS: We conducted a population-based case–control study including children with ASD ([Formula: see text]) and ID ([Formula: see text]) identified from the California Department of Developmental Services and general population (GP) controls ([Formula: see text]) from state birth certificates. ASD cases were matched to controls by sex, birth month, and birth year. Concentrations of 10 BFRs were measured in maternal second trimester serum samples stored from routine screening. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses. RESULTS: Geometric mean concentrations of five of the six congeners with [Formula: see text] of samples above the limit of detection were lower in mothers of children with ASD or ID than in controls. In adjusted analyses, inverse associations with several congeners were found for ASD relative to GP (e.g., quartile 4 vs. 1, BDE-153: [Formula: see text] , 95% CI: 0.38, 0.84). When stratified by child sex (including 99 females with ASD, 77 with ID, and 73 with GP), estimates were consistent with overall analyses in boys, but in the opposite direction among girls, particularly for BDE-28 and -47 ([Formula: see text] , 95% CI: 0.86, 7.79 and [Formula: see text] , 95% CI: 0.97, 7.19, respectively). Similar patterns overall and by sex were observed for ID. CONCLUSIONS: Contrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079 Environmental Health Perspectives 2017-08-30 /pmc/articles/PMC5783661/ /pubmed/28895873 http://dx.doi.org/10.1289/EHP1079 Text en EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
spellingShingle Research
Lyall, Kristen
Croen, Lisa A.
Weiss, Lauren A.
Kharrazi, Martin
Traglia, Michela
Delorenze, Gerald N.
Windham, Gayle C.
Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title_full Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title_fullStr Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title_full_unstemmed Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title_short Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case–Control Study in California
title_sort prenatal serum concentrations of brominated flame retardants and autism spectrum disorder and intellectual disability in the early markers of autism study: a population-based case–control study in california
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783661/
https://www.ncbi.nlm.nih.gov/pubmed/28895873
http://dx.doi.org/10.1289/EHP1079
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