The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms

The acquired kinase mutation JAK2V617F plays a central role in myeloproliferative neoplasms (MPNs). However, the mechanisms responsible for the malignant hematopoietic stem/progenitor cell (HSPC) expansion seen in patients with MPNs are not fully understood, limiting the effectiveness of current tre...

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Detalles Bibliográficos
Autores principales: Zhan, H, Lin, C H S, Segal, Y, Kaushansky, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783797/
https://www.ncbi.nlm.nih.gov/pubmed/28744010
http://dx.doi.org/10.1038/leu.2017.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783797/
https://www.ncbi.nlm.nih.gov/pubmed/28744010
http://dx.doi.org/10.1038/leu.2017.233

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