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Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy

Cardiac hypertrophy (CH) is a common disease that originates from long‐term heart pressure overload and finally leads to heart failure. Recently, long non‐coding RNAs (lncRNAs) have attracted attention because they have broad and crucial functions in regulating complex biological processes. Some stu...

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Autores principales: Zhang, Jian, Feng, Chenchen, Song, Chao, Ai, Bo, Bai, Xuefeng, Liu, Yuejuan, Li, Xuecang, Zhao, Jianmei, Shi, Shengshu, Chen, Xin, Su, Xiaojie, Li, Chunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783834/
https://www.ncbi.nlm.nih.gov/pubmed/29154475
http://dx.doi.org/10.1111/jcmm.13376
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author Zhang, Jian
Feng, Chenchen
Song, Chao
Ai, Bo
Bai, Xuefeng
Liu, Yuejuan
Li, Xuecang
Zhao, Jianmei
Shi, Shengshu
Chen, Xin
Su, Xiaojie
Li, Chunquan
author_facet Zhang, Jian
Feng, Chenchen
Song, Chao
Ai, Bo
Bai, Xuefeng
Liu, Yuejuan
Li, Xuecang
Zhao, Jianmei
Shi, Shengshu
Chen, Xin
Su, Xiaojie
Li, Chunquan
author_sort Zhang, Jian
collection PubMed
description Cardiac hypertrophy (CH) is a common disease that originates from long‐term heart pressure overload and finally leads to heart failure. Recently, long non‐coding RNAs (lncRNAs) have attracted attention because they have broad and crucial functions in regulating complex biological processes. Some studies had found that lncRNAs play vital roles in complex cardiovascular diseases. However, the function and mechanism of lncRNAs in CH have not been elucidated. In our study, to investigate the potential roles of lncRNAs in CH, the Cardiac Hypertrophy‐associated LncRNAs‐Protein coding genes Network (CHLPN) was constructed by integrating gene microarray re‐annotation and subpathway enrichment analyses. After performing random walking with restart in CHLPN, we predicted 21 significant risk lncRNAs, of which 7 (Kis2, 1700110K17Rik, Gm17501, E330017L17Rik, C630043F03Rik, Gm9866 and Ube4bos1) formed a close module with their co‐expressed protein‐coding genes (PCGs). We found that the module might play crucial roles in the development of CH. In particular, 44 PCGs that were co‐expressed with six lncRNAs were enriched in CH‐related biological processes and pathways. We also found that some lncRNAs participated in the competitive endogenous RNA cross‐talk that might be involved in CH. These results indicate that the functional lncRNAs are related to post‐transcriptional regulation and could shed light on a new molecular diagnostic target of CH.
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spelling pubmed-57838342018-02-08 Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy Zhang, Jian Feng, Chenchen Song, Chao Ai, Bo Bai, Xuefeng Liu, Yuejuan Li, Xuecang Zhao, Jianmei Shi, Shengshu Chen, Xin Su, Xiaojie Li, Chunquan J Cell Mol Med Original Articles Cardiac hypertrophy (CH) is a common disease that originates from long‐term heart pressure overload and finally leads to heart failure. Recently, long non‐coding RNAs (lncRNAs) have attracted attention because they have broad and crucial functions in regulating complex biological processes. Some studies had found that lncRNAs play vital roles in complex cardiovascular diseases. However, the function and mechanism of lncRNAs in CH have not been elucidated. In our study, to investigate the potential roles of lncRNAs in CH, the Cardiac Hypertrophy‐associated LncRNAs‐Protein coding genes Network (CHLPN) was constructed by integrating gene microarray re‐annotation and subpathway enrichment analyses. After performing random walking with restart in CHLPN, we predicted 21 significant risk lncRNAs, of which 7 (Kis2, 1700110K17Rik, Gm17501, E330017L17Rik, C630043F03Rik, Gm9866 and Ube4bos1) formed a close module with their co‐expressed protein‐coding genes (PCGs). We found that the module might play crucial roles in the development of CH. In particular, 44 PCGs that were co‐expressed with six lncRNAs were enriched in CH‐related biological processes and pathways. We also found that some lncRNAs participated in the competitive endogenous RNA cross‐talk that might be involved in CH. These results indicate that the functional lncRNAs are related to post‐transcriptional regulation and could shed light on a new molecular diagnostic target of CH. John Wiley and Sons Inc. 2017-11-20 2018-02 /pmc/articles/PMC5783834/ /pubmed/29154475 http://dx.doi.org/10.1111/jcmm.13376 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhang, Jian
Feng, Chenchen
Song, Chao
Ai, Bo
Bai, Xuefeng
Liu, Yuejuan
Li, Xuecang
Zhao, Jianmei
Shi, Shengshu
Chen, Xin
Su, Xiaojie
Li, Chunquan
Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title_full Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title_fullStr Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title_full_unstemmed Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title_short Identification and analysis of a key long non‐coding RNAs (lncRNAs)‐associated module reveal functional lncRNAs in cardiac hypertrophy
title_sort identification and analysis of a key long non‐coding rnas (lncrnas)‐associated module reveal functional lncrnas in cardiac hypertrophy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783834/
https://www.ncbi.nlm.nih.gov/pubmed/29154475
http://dx.doi.org/10.1111/jcmm.13376
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