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Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism

The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC‐1α pathway in putative neuroprotection. Wild‐type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+veh...

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Autores principales: Li, Xiang, Wang, Handong, Wen, Guodao, Li, Liwen, Gao, Yongyue, Zhuang, Zong, Zhou, Mengliang, Mao, Lei, Fan, Youwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783850/
https://www.ncbi.nlm.nih.gov/pubmed/29205806
http://dx.doi.org/10.1111/jcmm.13313
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author Li, Xiang
Wang, Handong
Wen, Guodao
Li, Liwen
Gao, Yongyue
Zhuang, Zong
Zhou, Mengliang
Mao, Lei
Fan, Youwu
author_facet Li, Xiang
Wang, Handong
Wen, Guodao
Li, Liwen
Gao, Yongyue
Zhuang, Zong
Zhou, Mengliang
Mao, Lei
Fan, Youwu
author_sort Li, Xiang
collection PubMed
description The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC‐1α pathway in putative neuroprotection. Wild‐type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBI‐induced neuronal apoptosis and ameliorated mitochondrial lesions. It significantly accelerated the translocation of PGC‐1α protein from the cytoplasm to the nucleus. In addition, quercetin restored the level of cytochrome c, malondialdehyde and superoxide dismutase in mitochondria. Therefore, quercetin administration can potentially attenuate brain injury in a TBI model by increasing the activities of mitochondrial biogenesis via the mediation of the PGC‐1α pathway.
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spelling pubmed-57838502018-02-08 Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism Li, Xiang Wang, Handong Wen, Guodao Li, Liwen Gao, Yongyue Zhuang, Zong Zhou, Mengliang Mao, Lei Fan, Youwu J Cell Mol Med Original Articles The aim of this study was to investigate the neuroprotective effects of quercetin in mouse models of traumatic brain injury (TBI) and the potential role of the PGC‐1α pathway in putative neuroprotection. Wild‐type mice were randomly assigned to four groups: the sham group, the TBI group, the TBI+vehicle group and the TBI+quercetin group. Quercetin, a dietary flavonoid used as a food supplement, significantly reduced TBI‐induced neuronal apoptosis and ameliorated mitochondrial lesions. It significantly accelerated the translocation of PGC‐1α protein from the cytoplasm to the nucleus. In addition, quercetin restored the level of cytochrome c, malondialdehyde and superoxide dismutase in mitochondria. Therefore, quercetin administration can potentially attenuate brain injury in a TBI model by increasing the activities of mitochondrial biogenesis via the mediation of the PGC‐1α pathway. John Wiley and Sons Inc. 2017-12-04 2018-02 /pmc/articles/PMC5783850/ /pubmed/29205806 http://dx.doi.org/10.1111/jcmm.13313 Text en © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Li, Xiang
Wang, Handong
Wen, Guodao
Li, Liwen
Gao, Yongyue
Zhuang, Zong
Zhou, Mengliang
Mao, Lei
Fan, Youwu
Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title_full Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title_fullStr Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title_full_unstemmed Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title_short Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
title_sort neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: pgc‐1α pathway as a potential mechanism
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783850/
https://www.ncbi.nlm.nih.gov/pubmed/29205806
http://dx.doi.org/10.1111/jcmm.13313
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