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Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing

The two presenilin‐1 (PS1) and presenilin‐2 (PS2) homologs are the catalytic core of the γ‐secretase complex, which has a major role in cell fate decision and Alzheimer's disease (AD) progression. Understanding the precise contribution of PS1‐ and PS2‐dependent γ‐secretases to the production of...

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Detalles Bibliográficos
Autores principales:	Stanga, Serena, Vrancx, Céline, Tasiaux, Bernadette, Marinangeli, Claudia, Karlström, Helena, Kienlen‐Campard, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783875/ https://www.ncbi.nlm.nih.gov/pubmed/28994238 http://dx.doi.org/10.1111/jcmm.13364

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