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Shielding and activation of a viral membrane fusion protein

Entry of enveloped viruses relies on insertion of hydrophobic residues of the viral fusion protein into the host cell membrane. However, the intermediate conformations during fusion remain unknown. Here, we address the fusion mechanism of Rift Valley fever virus. We determine the crystal structure o...

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Detalles Bibliográficos
Autores principales: Halldorsson, Steinar, Li, Sai, Li, Mengqiu, Harlos, Karl, Bowden, Thomas A., Huiskonen, Juha T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783950/
https://www.ncbi.nlm.nih.gov/pubmed/29367607
http://dx.doi.org/10.1038/s41467-017-02789-2