FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca(2+)], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats

Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca(2+) release, reverses aging-induced memory impairment and neuronal Ca(2+) dysregulation. Here, we tested the hypothesis that FKBP1b also can protect downstream transcriptional networks...

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Detalles Bibliográficos
Autores principales: Gant, John C., Blalock, Eric M., Chen, Kuey-Chu, Kadish, Inga, Thibault, Olivier, Porter, Nada M., Landfield, Philip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783960/
https://www.ncbi.nlm.nih.gov/pubmed/29255009
http://dx.doi.org/10.1523/JNEUROSCI.2234-17.2017

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