Vaccine vectors based on Adenovirus 19a/64 exhibit broad cellular tropism and potently restimulate HCMV-specific T cell responses ex vivo

Human Cytomegalovirus (HCMV) remains a major health burden and the development of a vaccine is a global priority. We developed new viral vectors delivering the T cell immunogens IE-1 and pp65 based on Adenovirus 19a/64 (Ad19a/64), a member of subgroup D. In this ex vivo study, the novel vectors were...

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Detalles Bibliográficos
Autores principales: Kiener, Richard, Fleischmann, Markus, Schwegler, Christiane, Ruzsics, Zsolt, Thirion, Christian, Schrödel, Silke, Asbach, Benedikt, Wagner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784015/
https://www.ncbi.nlm.nih.gov/pubmed/29367743
http://dx.doi.org/10.1038/s41598-018-19874-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784015/
https://www.ncbi.nlm.nih.gov/pubmed/29367743
http://dx.doi.org/10.1038/s41598-018-19874-1

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