Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson’s disease pathology. However, the significance of PREP protein for aSyn aggregation and toxicity is not known. We studied this in vivo by using PREP knock-out...

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Detalles Bibliográficos
Autores principales: Svarcbahs, Reinis, Julku, Ulrika H., Norrbacka, Susanna, Myöhänen, Timo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784134/
https://www.ncbi.nlm.nih.gov/pubmed/29367610
http://dx.doi.org/10.1038/s41598-018-19823-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784134/
https://www.ncbi.nlm.nih.gov/pubmed/29367610
http://dx.doi.org/10.1038/s41598-018-19823-y

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