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Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury

The objective of the present study was to evaluate protein carbonyl concentration as a predictor of AKI development in patients with septic shock and of renal replacement therapy (RRT) and mortality in patients with SAKI. This was a prospective observational study of 175 consecutive patients over th...

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Autores principales: Costa, Nara Aline, Gut, Ana Lúcia, Azevedo, Paula Schmidt, Tanni, Suzana Erico, Cunha, Natália Baraldi, Fernandes, Ana Angelica Henrique, Polegato, Bertha Furlan, Zornoff, Leonardo Antonio Mamede, de Paiva, Sergio Alberto Rupp, Balbi, André Luís, Ponce, Daniela, Minicucci, Marcos Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784177/
https://www.ncbi.nlm.nih.gov/pubmed/29263144
http://dx.doi.org/10.1042/BSR20171238
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author Costa, Nara Aline
Gut, Ana Lúcia
Azevedo, Paula Schmidt
Tanni, Suzana Erico
Cunha, Natália Baraldi
Fernandes, Ana Angelica Henrique
Polegato, Bertha Furlan
Zornoff, Leonardo Antonio Mamede
de Paiva, Sergio Alberto Rupp
Balbi, André Luís
Ponce, Daniela
Minicucci, Marcos Ferreira
author_facet Costa, Nara Aline
Gut, Ana Lúcia
Azevedo, Paula Schmidt
Tanni, Suzana Erico
Cunha, Natália Baraldi
Fernandes, Ana Angelica Henrique
Polegato, Bertha Furlan
Zornoff, Leonardo Antonio Mamede
de Paiva, Sergio Alberto Rupp
Balbi, André Luís
Ponce, Daniela
Minicucci, Marcos Ferreira
author_sort Costa, Nara Aline
collection PubMed
description The objective of the present study was to evaluate protein carbonyl concentration as a predictor of AKI development in patients with septic shock and of renal replacement therapy (RRT) and mortality in patients with SAKI. This was a prospective observational study of 175 consecutive patients over the age of 18 years with septic shock upon Intensive Care Unit (ICU) admission. After exclusion of 46 patients (27 due to AKI at ICU admission), a total of 129 patients were enrolled in the study. Demographic information and blood samples were taken within the first 24 h of the patient’s admission to determine serum protein carbonyl concentrations. Among the patients who developed SAKI, the development of AKI was evaluated, along with mortality and need for RRT. The mean age of the patients was 63.3 ± 15.7 years, 47% were male and 51.2% developed SAKI during ICU stay. In addition, protein carbonyl concentration was shown to be associated with SAKI. Among 66 patients with SAKI, 77% died during the ICU stay. Protein carbonyl concentration was not associated with RRT in patients with SAKI. However, the ROC curve analysis revealed that higher levels of protein carbonyl were associated with mortality in these patients. In logistic regression models, protein carbonyl level was associated with SAKI development (OR: 1.416; 95% CI: 1.247–1.609; P<0.001) and mortality when adjusted by age, gender, and APACHE II score (OR: 1.357; 95% CI: 1.147–1.605; P<0.001). In conclusion, protein carbonyl concentration is predictive of AKI development and mortality in patients with SAKI, with excellent reliability.
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spelling pubmed-57841772018-02-06 Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury Costa, Nara Aline Gut, Ana Lúcia Azevedo, Paula Schmidt Tanni, Suzana Erico Cunha, Natália Baraldi Fernandes, Ana Angelica Henrique Polegato, Bertha Furlan Zornoff, Leonardo Antonio Mamede de Paiva, Sergio Alberto Rupp Balbi, André Luís Ponce, Daniela Minicucci, Marcos Ferreira Biosci Rep Research Articles The objective of the present study was to evaluate protein carbonyl concentration as a predictor of AKI development in patients with septic shock and of renal replacement therapy (RRT) and mortality in patients with SAKI. This was a prospective observational study of 175 consecutive patients over the age of 18 years with septic shock upon Intensive Care Unit (ICU) admission. After exclusion of 46 patients (27 due to AKI at ICU admission), a total of 129 patients were enrolled in the study. Demographic information and blood samples were taken within the first 24 h of the patient’s admission to determine serum protein carbonyl concentrations. Among the patients who developed SAKI, the development of AKI was evaluated, along with mortality and need for RRT. The mean age of the patients was 63.3 ± 15.7 years, 47% were male and 51.2% developed SAKI during ICU stay. In addition, protein carbonyl concentration was shown to be associated with SAKI. Among 66 patients with SAKI, 77% died during the ICU stay. Protein carbonyl concentration was not associated with RRT in patients with SAKI. However, the ROC curve analysis revealed that higher levels of protein carbonyl were associated with mortality in these patients. In logistic regression models, protein carbonyl level was associated with SAKI development (OR: 1.416; 95% CI: 1.247–1.609; P<0.001) and mortality when adjusted by age, gender, and APACHE II score (OR: 1.357; 95% CI: 1.147–1.605; P<0.001). In conclusion, protein carbonyl concentration is predictive of AKI development and mortality in patients with SAKI, with excellent reliability. Portland Press Ltd. 2018-01-25 /pmc/articles/PMC5784177/ /pubmed/29263144 http://dx.doi.org/10.1042/BSR20171238 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Costa, Nara Aline
Gut, Ana Lúcia
Azevedo, Paula Schmidt
Tanni, Suzana Erico
Cunha, Natália Baraldi
Fernandes, Ana Angelica Henrique
Polegato, Bertha Furlan
Zornoff, Leonardo Antonio Mamede
de Paiva, Sergio Alberto Rupp
Balbi, André Luís
Ponce, Daniela
Minicucci, Marcos Ferreira
Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title_full Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title_fullStr Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title_full_unstemmed Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title_short Protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
title_sort protein carbonyl concentration as a biomarker for development and mortality in sepsis-induced acute kidney injury
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784177/
https://www.ncbi.nlm.nih.gov/pubmed/29263144
http://dx.doi.org/10.1042/BSR20171238
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