An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

The antibiotic paenimucillin A was originally identified using a culture-independent synthetic-bioinformatic natural product (syn-BNP) discovery approach. Here we report on a bioinformatics-guided survey of paenimucillin A analogs that led to the discovery of paenimucillin C. Paenimucillin C inhibit...

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Detalles Bibliográficos
Autores principales: Vila-Farres, Xavier, Chu, John, Ternei, Melinda A., Lemetre, Christophe, Park, Steven, Perlin, David S., Brady, Sean F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784245/
https://www.ncbi.nlm.nih.gov/pubmed/29404414
http://dx.doi.org/10.1128/mSphere.00528-17

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